摘要
目的探讨丹参酮ⅡA治疗急性脑梗死的疗效及作用机制。方法104例急性脑梗死病人随机分为两组,对照组进行基础治疗,治疗组在基础治疗的同时给予丹参酮ⅡA静脉注射,观察治疗前后神经功能缺失评分、Barthel指数及血浆6-酮-前列腺素(6-Keto-PGF1α)、血栓素B2(TXB2)、超氧化物歧化酶(SOD)、脂质过氧化物(LPO)、丙二醛(MDA)水平的变化。结果治疗组治疗后神经功能缺损评分明显下降为4.62分±1.61分,Barthel指数升高为70.19±10.04,6-Keto-PGF1α含量及SOD活性明显升高,TXB2及LPO、MDA含量显著下降,与对照组治疗后比较均有统计学意义(P<0.05)。结论丹参酮ⅡA具有明显抑制血小板活化及清除自由基等作用,治疗急性脑梗死有肯定的疗效。
Objective To investigate the effect of tanshinone 11 a on acute cerebral infarction Methods One hundred and thirty patients with acute cerebral infarction were randomly divided into two groups： Control group treated with conventional therapy and tanshinone Ⅱ a group treated with tanshinone Ⅱ a. Neurological functional deficit scores, barthel index （BI）, 6-Keto- PGF1a, TXB2, superoxide dismutas （SOD）, lipid peroxide. （LPO） and malondialdehyde （MDA） were observed pre-and post-treatment. Results In treatment group, the neurological functional deficit scores were decreased, the barthel index, the level of 6-Keto- PGF1a and SOD were increased and the level of TXB2, LPO and MDA were decreased. There were significant differences between two groups, Conclusion Tanshinone Ⅱ a showed definite effect for cerebral infarction and it could inhibit activity of platelet and decreas the level of the free radical.
出处
《中西医结合心脑血管病杂志》
2008年第4期401-402,共2页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
关键词
丹参酮ⅡA
脑梗死
急性
神经功能缺失评分
tanshinone Ⅱ a
cerebral Infarction
neurological functional deficit scores
Barthel index
