摘要
人类runt相关转录因子3(RUNX3)基因是新近发现的一种抑癌基因,目前认为其失活的主要机制是高甲基化和杂合性缺失。RUNX3基因可能为转化生长因子-β(TGF-β)转导通路中的一个重要环节,参与TGF-β上皮细胞生长的负调控。大量研究已表明RUNX3与胃癌、肺癌、内胚窦癌、胰腺癌、胆管癌、肝癌、结肠癌、前列腺癌等多种肿瘤的发生发展有密切关系,并且RUNX3基因启动子的过度甲基化是导致RUNX3低表达,促进肿瘤发生发展的一个重要因素。
Human runt - related transcription factor 3 （RUNX3） is a newly discovered tumor suppressor gene. Hypermethylation and loss of heterozygosity are the principal mechanism of its inactivation. RUNX3 is an important link of transforming growth factor-beta （TGF -beta） pathway, and negative-regulate the growth of TGF -beta epithelial cells. A lot of research has shown RUNX3 has closely related with the developememt of many tumors ,such as gastric cancer, lung cancer, endodermal sinus cancer, pancreatic cancer, cholangiocarcinoma, liver cancer,colon cancer, prostate cancer. And RUNX3 promoter hypermethylation is a vital factor that lead to the low expression of RUNX3 and promote tumor development.
出处
《现代肿瘤医学》
CAS
2008年第5期858-861,共4页
Journal of Modern Oncology
