摘要
目的:评价介入封堵术对小儿先天性心脏病(CHD)患者血浆组织型纤溶酶原激活物(t-PA)和纤溶酶原激活物抑制物-1(PAI-1)水平的影响。方法:采用酶联免疫吸附法检测70例CHD患者及30例健康人(正常对照组)血浆t-PA、PAI-1水平。所有CHD患者分别于介入封堵术前1d、术后24h、1、3、6、12个月检测血浆t-PA、PAI-1水平。结果:介入封堵术前,CHD患者血浆t-PA、PAI-1水平比正常对照组明显增高(P<0.01)。介入封堵术后1个月,CHD组血浆PAI-1水平开始逐渐下降,术后6个月恢复正常水平;血浆t-PA水平在术后1个月升高,术后3个月始下降,术后6个月恢复正常水平。结论:介入封堵术可通过改变血浆t-PA、PAI-1水平而改善小儿CHD患者的内源性纤溶功能。
Objective：To evaluate the effects of transcatheter closure on plasma tissue plasminogen activator （t-PA） and plasminogen activator inhibitor-1 （PAI-1） in children patients with congenital heart disease （CHD）. Methods： The levels of plasma t-PA and PAL-1 were detected in 70 patients with CHD and in 30 normal controls by enzyme-linked immunosorbent assay. The levels of plasma t-PA and PAL1 in patients were detected one day before transcatheter closure and 24 hours, 1 month, 3 months, 6 months, 12 months after transcatheter closure. Result： Compared with the normal controls, the levels of plasma t-PA and PAI-1 in patients with CHD were significantly increased （ P d0.01）. The level of plasma PAL-1 began to decrease in 1 month after transcatheter closure, and it was near the normal level in 6 months. The level of plasma t-PA began to increase at 1 month after transcatheter closure, while decreasing in 3 months, and it was near the normal level in 6 months. Conclusion; Transcatheter closure can improve fibrinolytic function of children patients with CHD by changing the levels of plasma t-PA and PAL-1.
出处
《广西医科大学学报》
CAS
北大核心
2008年第1期21-22,共2页
Journal of Guangxi Medical University
基金
广西科技攻关项目(桂科攻No0472002-30)
