摘要
家兔静脉注射重组葡激酶(r-Sak)后,经用二室模型(权重系数1/C)计算。结果表明,该药分布相较短,t1/2α约为1.11±0.72 min,消除也快,t1/2β约为8.64±0.21min,但在胆汁及尿液中未测出r-Sak的生物活性。
The pharmacokinetic parameters of Human recombinant staphylokinase were studied with analyzing fibrinolytic activity method. The plasma concentration-time curve of r-Sak after iv 1. 35, 0. 45 mg/kg into rabbits was found to fit a two-compartment model,tl/2@ was 1. 11@0. 72 min and tl/2@ was 8. 64@0. 21 min. It was shown that r-Sak eliminated from plasma was very fast. r-Sak was not found in bile and urine.
出处
《天然产物研究与开发》
CAS
CSCD
1997年第2期71-75,共5页
Natural Product Research and Development
关键词
重组葡激酶
药代动力学
药理学
Recombinant staphylokinase (r-Sak),Pharmacokinetic parameters,Rabbit
