摘要
目的:观察重组牛胰蛋白酶抑制剂(rBPTI)对大鼠急性坏死性胰腺炎(ANP)的治疗作用。方法:取大鼠60只,随机分成6组:假手术组、模型组、rBPTI的3个剂量组、抑肽酶组。注射牛磺胆酸钠建立大鼠ANP模型,股静脉注射给药48h后,测定大鼠血清和组织淀粉酶和脂肪酶含量,观察胰腺组织病理变化。结果:rBPTI治疗组可明显降低血清和组织淀粉酶、脂肪酶的浓度,与模型组比较差异有统计学意义(P<0.05,P<0.01),且使胰腺的病理变化减轻。结论:rBPTI对牛磺胆酸钠诱导大鼠ANP具有治疗作用,作用效果同天然BPTI相当。
Objective： To observe the effect of recombinant boVine pancreatic trypsin inhibitor（rBPTI） on acute necrosis pancreatitis（ANP）in rats. Method： Sixty rats was randomly divided into six groups： a sham-operated control group, a ANP model group, ANP ＋ rBPTI group （including lower dosage, medium dosage, maximum dosage） and ANP ＋ BPTI group. ANP was induced by injection of sodium taurocholate into the main pancreatic duct Of rats. After 48 h of administration through vena femoralis injection, the levels of amylase and lipase in serum and tissue were assayed and pathological changes were observed. Result： rBFTI group compared with model group, the levels of amylase and lipase in serum and tissue were markedly decreased, and they were statistically significant （P 〈 0.05, P 〈 0.01, respectively）. The pathological change was ameliorated significantly after treatment with rBPTI. Conclusion： The rBP- TI had therapeutic effect on ANP in rats as BPTI.
出处
《中国药师》
CAS
2008年第4期375-377,共3页
China Pharmacist
关键词
重组牛胰蛋白酶抑制剂
牛胆磺酸钠
急性坏死性胰腺炎
大鼠
Recombinant bovine pancreatic trypsin inhibitor （rBPTI）
Sodium taurocholate
Acute necrosis pancreatitis （ANP）
Rats
