摘要
目的:探讨在基层医院进行双鼻塞持续气道正压通气(CPAP)与盐酸氨溴索联合应用治疗新生儿呼吸窘迫综合征(NRDS)的疗效及临床价值。方法:对23例NRDS患儿进行CPAP通气的同时给盐酸氨溴索静脉注射加雾化治疗,观察治疗前后的血氧饱和度、X线胸片和临床效果。结果:与用药前相比,用药后6 h SpO_2即明显升高,至12 h、24 h、36 h SpO_2仍持续稳定在较高水平,差异有统计学意义。用药6 h,呼吸窘迫症状消失4例(17.4%),明显改善18例(78.3%),未减轻3例;48 h后,X线胸片显示肺野透明度明显改善18例(78.3%)。23例中治愈20例(87%),1例死亡,2例家属签字放弃治疗。结论:CPAP与盐酸氨溴索联合应用治疗NRDS临床效果满意,经济有效,依从性好,值得在基层医院推广。
Object：To discuss the effects and the value of the continuous positive airway pressure （CPAP） combined with ambroxol for the double stuffy nose in treatment of neonatal respiratory distress syndrome （NRDS） in the hospital on primary level. Methods： 23 cases of NRDS were treated with the CPAP when ambroxol was added intravenously with atomization treatment, and then saturations of blood oxygen, X sternum and clinic effects were observed before and after the treatment. Results： Compared with those before the medication, SpO2 was obviously higher 6 hours after the medication and remained on high level 12, 24 and 36 hours after, with a significant statistical difference. Respiratory embarrassment symptom disappeared in 4 cases （17.4%） and improved in 16 cases （69.6%） and remained the same in 3 cases. After 48 hours, X sternum demonstrated improvement in the lung field transparency in 18 cases （78.3%）. In 23 cases, 20 recovered （87%）, 1 dyed, and 2 were given up treatment with family agreement. Conclusions： The clinic effect of CPAP combined with ambroxol hydrochloride in treatment of the NRDS is effective and economic with a good compliance and worth promoting in primary hospitals.
出处
《儿科药学杂志》
CAS
2008年第2期20-22,共3页
Journal of Pediatric Pharmacy
关键词
盐酸氨溴索
肺表面活性物质
双鼻塞持续气道正压通气
呼吸窘迫综合征
Pulmonary suffactant
The double stuffy nose to continuous positive airway pressure
Neonatal respiratory distress syndrome
