摘要
对于放射治疗中发生的急性和晚期放射性损伤,目前尚未能建立临床适用的预测放射性损伤模型。各种研究希望通过探寻DNA损伤、修复基因的多态性与放射性损伤之间的关系来了解放射性损伤的分子机制。基因的多态性不但可以改变蛋白的功能,还可能影响到个体正常组织对受损DNA修复的能力。ATM、XRCC1、BRCA1/2、ERCC2、SOD2、DNA ligaseⅣ和TGF-β1等基因的SNPs与增加放射性损伤可能性相关,这些基因是目前有关放射性损伤研究的活跃领域。未来在放射性损伤相关性的研究中,只能依靠大样本量、严格的对照研究才能获得确实意义的结论。
Clinically applicable radiation injuny models are still unavailable for the acute and advanced radiation - related injuries. Recent researches focusing on the underlying molecular mechanisms assess associations between common polymorphisms in DNA damage detection and repair genes and the development of the adverse reactions to radiotherapy. The presence of the variants may alter not only protein function, but also the capacity to repair damage DNA modifying the response of the normal tissue. Single nucleotide polymorphisms （SNPs） in genes related to the biological response to ionising radiation may affect clinical radiation sensitivity. SNPs of ATM, XRCC1, BRCA1/2, ERCC2, SOD2, DNA ligase IV and TGF -β1 genes may have potential associations with an increased risk of developing an adverse normal tissue reaction to radiotherapy.
出处
《癌症进展》
2008年第2期141-146,162,共7页
Oncology Progress
关键词
单核苷酸多态性
SNP
放射性损伤
放射敏感性
Single nucleotide polymorphisms Normal tissue reactions after radiotherapy Radiation sensitivity
