摘要
目的:检测缺氧诱导因子-1α(HIF-1α)和BNIP3在喉癌组织中的表达及相关性。方法:采用SP免疫组织化学方法对45例喉癌组织、12例癌旁正常黏膜组织中HIF-1α和BNIP3的表达进行检测。结果:HIF-1α、BNIP3表达于细胞质及细胞核,喉癌组织中的HIF-1α和BNIP3的表达高于癌旁正常黏膜组织(P<0.05),并且两者的表达呈正相关(P<0.05)。结论:HIF-1α与BNIP3在喉癌中的高表达密切相关。两者的高表达在喉癌的发生发展中可能具有重要作用,HIF-1α可能诱导BNIP3的表达,针对HIF-1α和BNIP3的靶向治疗有望成为新的治疗方法。
Objective：To investigate the expression of Hypoxia inducible factor-1α（HIF-1α）and the Bcl-2/adenovirus E1B 19 kDa-interacting protein 3（BNIP3） in human laryngeal carcinoma and their relationship.Method：The expression of HIF-1αand BNIP3 were deteced by SP immunohistochemical method in 45 cases with laryngeal carcinoma tissues and 12 adjacent normal laryngeal tissue.Result：The expression of HIF-1αand BNIP3 were mainly in cytoplasm and nucleus.Their expression was higher in laryngeal tissue than in adjacent normal laryngeal tissue（P〈0.05）.The expression of HIF 1αwas positively related to that of BNIP3 in laryngeal carcinoma tissues（P〈0.05）.Conclusion：The high expression of HIF-1αand BNIP3 were closely related in laryngeal carcinomas,both of them played important role in the carcinogenesis and development of laryngeal carcinoma.HIF-1α might induce the expression of BNIP3.HIF-1αand BNIP3 might to be two potential therapeutic targets in laryngeal squamous cell carcinomas.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
CSCD
北大核心
2008年第3期112-114,共3页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
