摘要
铜绿假单胞菌接种于含次抑菌浓度的哌拉西林和阿米卡星的营养肉汤中，葡萄球菌接种于次抑菌浓度的氧氟沙星和环丙沙星的营养肉汤中，经传代培养可获得相对应的耐药菌株。哌拉西林诱导耐药的铜绿假单胞菌对头孢他啶亦耐药，但对阿米卡星、环丙沙星、亚胺培南／西司他丁不耐药；阿米卡星诱导耐药的铜绿假单胞菌对哌拉西林亦耐药，但对头孢他啶、环丙沙星、亚胺培南／西司他丁没有交叉耐药；氧氟沙星或环丙沙星诱导耐药的葡萄球菌对氟喹诺酮类药物都有交叉耐药，但对苯唑西林、阿米卡星。
P.aeruginosa was incubated with broth subinhibitory concentration of piperacillin or amikacin. In the same way Staphylococcus was transferred with broth subinhibitory concentration of ofloxacin or ciprofloxacin. Bacterial resistant species cor responding to antibiotics were obtained. Piperacillin resistant P.aeruginosa showed resis tance to ceftazidime, but none of species showed cross resistance to amikacin, ciprofloxacin, or imipenem/cilastatin. Amikacin resistant P.aeruginesa showed resistance to piperacillin, but none of species showed cross resistance to ceftazidime, ciprofloxacin, or imipenem/cilastatin. Ofloxacin or ciprofloxacin resistant Staphylococcus showed cross resistance to other fluoroquinolones, but none of species showed cross resistance to oxacillin, amikacin, or imipenem/cilastatin.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
1997年第4期301-303,共3页
Chinese Journal of Antibiotics
关键词
铜绿假单胞菌
次抑菌浓度
细菌
耐药性
抗菌药物
P.aeruginosa , Staphylococcus, Subinhibitory concentration, Resistance, Cross resistance
