摘要
目的 研究蛛网膜下腔出血 (SAH)后脑血管痉挛的病理变化。 方法 将 6例SAH死亡病例 ,与同期同年龄段 2 0例癌症及 40例脑出血作对照 ,着重对脑内外动脉进行病理观察及形态定量分析。 结果 1 病理检查发现 ,被凝血块包埋的动脉有内膜肿胀 ,内膜下基质增多 ,内弹力板多皱折 ,平滑肌细胞变性 ,肌细胞或肌层坏死等改变。 2 SAH组与对照组、脑出血组与对照组比较 ,脑内外动脉的管腔变小、管壁增厚 ,差异有显著意义 (P <0 0 1 ) ,而SAH组与脑出血组比较 ,仅被凝血块包埋的小动脉管腔明显减小 ,管壁明显增厚 (P <0 0 1 )。 结论 本研究结果提示SAH后 ,被蛛网膜下腔凝血块包埋的脑动脉发生较明显的血管痉挛 ,痉挛血管既有收缩性变化 。
Objective The aim of the study was to investigate pathological change of cerebral blood vessel following subarachnoid hemorrhage(SAH). Methods The 66 consecutive autopsy cases(aged 50～80 years) were studied, including 6 cases of SAH, 40 cases of cerebral hemorrhage(CH) and 20 cases of cancer (as control group) respectively. The medium sized and small intracranial arteries, small intracerebral arteries were examined by light microscopy and measured by computer. Results 1 The histological examination of the arteries coated in blood clots of the subarachnoid space had revealed the endothelial cell swelling, thickening of the subinitimal interstitial space, corrugation of the internal elastic lamina, degenaration and necrosis in unstriped muscle cell or tunica media~. 2 The arteries measured in SAH as well as CH groups appeared much more luminal narrowing and thickening of vessel wall than those in control group ( P <0 01). Luminal narrowing and thickening of wall of small intracranial arteries coated in blood clots in SAH group were more obvious than in CH group. Conclusions These data suggest that intracranial arteries coated in blood clots appear severe cerebral vasospasm following SAH. The spasic arteries had both vascular constricting and organic narrowing changes.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
1997年第4期193-195,共3页
Chinese Journal of Nervous and Mental Diseases
基金
军队九五基金资助 (批准编号 96B0 0 3)
关键词
蛛网膜下腔出血
病理学
脑血管
Subarachnoid hemorrhage Vasospasm Blood vessel pathology
