摘要
以氰化钠、碳酸铵、乙醛等为原料，常压下一步反应得到５甲基海因，总收率７０２％。其最佳操作条件为：反应温度７５℃，反应时间３ｈ，原料碳酸铵与氰化钠之比为２∶１，酸化回流ｐＨ值为２，酸化回流时间２ｈ。
The synthesis of 5 methyl hydantoin from NaCN, (NH 4) 2CO 3 and CH 3CHO under normal pressure in only one step is proposed. The pure product can be obtained by recrystalization. The optimal operating canditions of the synthesis are: reaction temperature 75℃, reaction time 3 h, the feeding ratio of NaCN to (NH 4) 2CO 3 1∶2, the pH value 2, the acidified reflux time 2 h.
出处
《南京化工大学学报》
1997年第3期78-81,共4页
Journal of Nanjing University of Chemical Technology(Natural Science Edition)
基金
国家科委"九五"攻关项目
关键词
一步法
甲基海因
丙氨酸
海因
one step\ 5 methyl hydantoin\ D amino acid
