期刊文献+

衍生化HPLC法检测血浆、尿液左卡尼汀及其代谢产物 被引量:2

下载PDF
导出
摘要 用衍生化HPLC法测定血浆和尿液左卡尼汀(LC)、乙酰左卡尼汀(ALC)、丙酰左卡尼汀(PLC)水平。采用Hypersil C18色谱柱,流动相为乙腈∶乙酸铵(34∶66),流速1 ml/min,检测波长Ex248 nm,Em418 nm。结果显示,血浆和尿液LC、ALC、PLC样品的线性范围、回收率、精密度及稳定性均符合血、尿检测方法学要求。认为本方法检测LC、ALC和PLC血药、尿药浓度灵敏、稳定,结果准确,操作方便。
出处 《山东医药》 CAS 北大核心 2008年第10期95-96,共2页 Shandong Medical Journal
  • 相关文献

参考文献2

  • 1林锋.左卡尼汀在全肠外营养中的应用.中华胃肠道杂志,2003,3(1):42-42. 被引量:7
  • 2Laurence V,Michael D,Jurg S,et al. Effect of L-carnitine on the kinetics of camitine,acylcamitines and butyrobetaine in long-term haemodialysis[ J]. Nephrol Dial Transplant, 2006, 21 (2) : 450-458. 被引量:1

共引文献6

同被引文献13

  • 1方天富,王平,唐凤琴,郭航远.左卡尼汀治疗扩张型心肌病心力衰竭临床观察[J].浙江临床医学,2006,8(8):829-829. 被引量:2
  • 2Richards P, McKenna W, Bris tow W, et al. Report of the 1995 World Organization/International Society and Feder- ation of Cardiology Task Force on the definition and clas- sification of cardiomyopathies[J]. Circulation, 1996, 93 .. 841. 被引量:1
  • 3John DF, Austin LS, Joseph RK, et al. Proteetion of the Ischemic Dog Myocardium with Carnitine[J]. Am J Card# ol, 1978,41(7). 1 209. 被引量:1
  • 4Kemer J, Hoppel C. Generic disorders of carnitinemetabo- lism and their nutritional management[J]. Annu Rev Nutr, 1998,18: 179. 被引量:1
  • 5Suxuki Y, Kamikawa T, Yamazaki N. Effects of L-carni- tine on wentricular arrhythmias in dogs with acute myo- cardal ischemia and a supplement of excess free fatty acids [J]. Jpn CireJ, 1981,45(5) :552. 被引量:1
  • 6El-Aroussy W, Rizk A, Mayhoub G, et al. Plasma carni- tine levels as a marker of impaired left entricular functions [J]. Molecular and Cellular Biochemistry, 2000, 213 ( 1/ 2):37. 被引量:1
  • 7Rizos I. Three-year survival of patients with heart failure caused by dilated cardiomyopathy and L-carnitine admin- istration[J]. Am Heart J, 2000,139 ( 2 Pt 3 ) : S 120. 被引量:1
  • 8Cao Y, Wang YX, Liu C J, et al. Comparison of pharma- cokinetics of L-carnitine, acetyl-L-carnitine and propio- nyl-L-camitine after single oral administration of L-cami- tine in healthy volunteers[J]. Clin Invest Med, 2009, 32 (1):E13. 被引量:1
  • 9Squarcia U, Agnetti A, Caffarra A, et al, Dilated cardio- myopathy due to primary camitine deficiency[J]. Pedi- atrl Med Chir , 1986,8(2) : 157. 被引量:1
  • 10P. Vreken,A. E. M. van Lint,A. H. Bootsma,H. Overmars,R. J. A. Wanders,A. H. van Gennip. Quantitative plasma acylcarnitine analysis using electrospray tandem mass spectrometry for the diagnosis of organic acidaemias and fatty acid oxidation defects[J] 1999,Journal of Inherited Metabolic Disease(3):302~306 被引量:1

引证文献2

二级引证文献4

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部