摘要
研究了羟丙基-β-环糊精对格列吡嗪的包结作用,考察了包结物的性质。通过相溶解度法确定了羟丙基-β-环糊精与格列吡嗪二者的包结摩尔比和包结稳定常数,采用中和法制备了羟丙基-β-环糊精/格列吡嗪固体包结物,并通过傅里叶变换红外光谱、差式扫描量热分析、X射线粉末衍射光谱对羟丙基-β-环糊精/格列吡嗪固体包结物进行了表征。结果表明,格列吡嗪与羟丙基-β-环糊精的相溶解度图为典型的AL型,两者形成了1:1的可溶性包结物,在25℃时包结物平衡常数(K1:1)为359L·mol-1。羟丙基-β-环糊精/格列吡嗪包结物的光谱研究结果表明,羟丙基-β-环糊精/格列吡嗪包结物是格列吡嗪以无定形状态分散到羟丙基-β-环糊精中。包结物的水溶性实验结果表明包结后格列吡嗪的溶解度增加了25倍。
The interaction of glipizide and hydroxypropyl-β-cyclodextrin was investigated in the
present paper.The stability constant and molar ratio of glipizide and
hydroxypropyl-β-cyclodextrin was calculated from the phase soluility diagram.The solid state
inclusion complex of hydroxypropyl-β-cyclodextrin/glipizide prepared by neutralization method
was characterized by Fourier transform infrared spectroscopy（FTIR）,differential scanning
calorimetry（DSC） and powder X-ray diffraction（XRD）.It was found that the phase solubility diagram
of the HP-β-CD solution showed a typical AL-type,suggesting the formation of a soluble complex
of 1：1 molar ratio,and the stability constant was 359 L·mol^-1 at 25 ℃.The spectra of
IR,thermograph of DSC and XRD pattern of the inclusion complex were remarkably different from the
glipizide and hydroxypropyl-β-cyclodextrin/glipizide physical mixture,and indicated that
hydroxypropyl-β-cyclodextrin/glipizide inclusion complex displayed amorphous characteristic.The
experiment of solubility of inclusion complex indicated that the solubility of inclusion complex
increased 25-fold.
出处
《光谱学与光谱分析》
SCIE
EI
CAS
CSCD
北大核心
2008年第3期711-714,共4页
Spectroscopy and Spectral Analysis
基金
天津市科委自然科学基金项目(030024)资助
