摘要
目的:检测三十烷醇原药的急性经口、经皮毒性和对眼、皮肤的刺激性以及对皮肤的致敏性,为三十烷醇原药的安全使用提供毒理学依据。方法:急性经口、经皮毒性试验,眼、皮肤刺激试验以及皮肤致敏试验均按中华人民共和国国家标准《农药登记毒理学试验方法》(GB15670-1995)的规定方法进行。结果:三十烷醇原药对雄性大鼠和雌性大鼠的经口LD50均>5000mg/kg,经皮LD50均>2000mg/kg;对大耳白兔眼刺激积分指数为4,眼刺激平均指数48h后为0,对豚鼠皮肤刺激积分为0,对豚鼠致敏率为0,结论:三十烷醇原药急性经口、经皮毒性为低毒,且属于弱致敏物,对人畜较为安全。
Aim： To test the acute oral and dermal toxicity, the skin and eye irritability, and the dermal delayed hypersensitivity reactions of triacontanol, and to provide toxicological data for using triacontanol safely. Methods：All of tests including the acute oral and dermal toxicity, eye,skin,and the dermal delayed hypersensitivity reaction were based on the Chinese standards of ＂toxicological test methods of pesticides for registration＂. Results： The LD50 of triacontanol were over 5 000 mg/kg by oral and over 2 000 mg/kg by skin in rats. The highest index of ophthalmol irritation was 4 in rabbits. The mean index of ophthalmol irritation was 0 after 48 h in rabbits. The skin irritability index was 0 in guinea pigs,and the sensitization ratio was 0 in guinea pigs. Conclusion： The acute oral and dermal toxicity of triacontanol is low, and it is a weak sensitizer, which is safe for human being and domestic animals.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2008年第2期364-366,共3页
Journal of Zhengzhou University(Medical Sciences)
关键词
三十烷醇
急性毒性
刺激
致敏
triacontanol
acute toxicity
irritation
sensitization
