摘要
目的：研究心脑血管疾病患者血清脂蛋白（ａ）水平及与其他脂类（ＣＨＯ、ＴＧ、ＡｐｏＡ１、ＡｐｏＢ）的关系，进一步阐明血清脂蛋白（ａ）为心脑血管疾病的独立危险因素，支持脂蛋白（ａ）水平的检测具有极为重要的意义。方法：采用Ｅｌｉｓａ双抗体夹心法、免疫浊度法和酶法分别测定急性脑血管病６７例（脑出血３１例，多发性脑梗塞３６例）、冠心病４５例、高血压５０例和９８例健康人的血清脂蛋白（ａ）及其血脂（ＣＨＯ、ＴＧ、ＡｐｏＡ１、ＡｐｏＢ）含量。结果：脑出血、脑梗塞、冠心病和高血压患者血清脂蛋白（ａ）的含量分别为：３８８１９±２１８５２ｍｇ／Ｌ、４３８２５±２１９０３ｍｇ／Ｌ、３５０３６±１５９０３ｍｇ／Ｌ和２２６２１±１１６９４ｍｇ／Ｌ，与健康对照组（１８０５７±１０１３３ｍｇ／Ｌ）相比，Ｐ＜００１。血清脂蛋白（ａ）水平变化与ＣＨＯ、ＴＧ、ＡｐｏＡ１、ＡｐｏＢ含量无明显相关性。结论：血清脂蛋白（ａ）浓度升高与心脑血管疾病密切相关，故作为心脑血管疾病的独立危险因素是十分有意义的。血脂（ＣＨＯ、ＴＧ、ＡｐｏＡ１、ＡｐｏＢ）浓度变化对心脑血管疾病的危险性预测有很好价值。这些指标异常既是心脑血管疾病的危险因素，?
Objective:To study the corelation of lipoprotein Alevel to that of other lipoproteins in serum of the patients with cardiocerebrovascular diseases.Methods:Immune turbidity enzyme assay and ELISA diantigen sandwich method are used for determinating ApoA 1,CHO,TG and Lp(a) level in serum of the patients with cardiocerebrovascular disease.Results:The concentrations of Lp(a) are 388 19±218 52 mg/L in cerebral hemorrhage,438 25±219 03 mg/L in multi cerebral infarction,350 36±159 03 mg/L in coronary heart diseases and 226 21±116 94 mg/L in hypertension patients,separately.They are all obviously higher than that of the normal control(180 57±101 33 mg/L)( P <0 01).There is no obvious relationship between the Lp(a) level and concentrations of CHO,TG,ApoA 1 and ApoB.Conclusion:The high concentration of Lp(a) is closely related to the development of cardiocerebrovascular diseases.It is suggested that the serum Lp(a) may be an independent risk factor in the development of cardiocerebrovascular diseases.The concentrations of other lipoprotein(CHO,TG,ApoA 1,ApoB)are also important for the diagnosis of cardiocerebrovascular diseases.
出处
《中日友好医院学报》
1997年第3期213-216,共4页
Journal of China-Japan Friendship Hospital
关键词
脑出血
脑梗塞
冠心病
高血压
载脂蛋白
cerebral hemorrhage
cerebral infarction
coronary heart disease
hypertension
lipoprotein(a)
apolipoprotein
