摘要
Survivin是新发现的凋亡抑制蛋白(Inhibitor of apoptosis protein,IAP)家族的成员,正常胃黏膜中Survivin的表达呈缺失状态,胃癌细胞系中Survivin-mRNA阳性率为100%;凋亡对机体很重要,在正常情况下可消灭DNA受损或细胞循环周期失调的细胞,即有恶变潜能的细胞,凋亡机制受损则促进肿瘤的进展和转移,并使癌细胞能抗拒多种治疗方法。Survivin在胃癌中呈特异性高表达,并有抑制细胞凋亡,调控细胞周期,参与血管形成的作用;胃癌中Survivin的过表达在mRNA和蛋白水平,它可能在癌的侵袭和转移中起作用,是检测胃癌微转移的一个潜在的分子学指标;Survivin与癌细胞的化疗抗药性密切相关。总结了Survivin在胃癌发病机制中的作用及诊疗中的研究进展。
Survivin is a new member in inhibitor of apoptosis family of protein （lAPs）, and it has imperfect expression in normal stomach mucosa, but the positive ratio of Survivin-mRNA is 100% in carcinoma cell line （CCL） of gastric cancer. It is important that apoptosis can eliminate damaged DNA or disturbance cells in period of batching cycle which has canceration potency to organism. If apoptosis mechanism is damaged it will promote advancement and metastasis in tumor and resist many therapy in malignant cells, respectively. Survivin has a higher expression specificity in gastric cancer, and it has important effectiveness which restraining apoptosis,controlling cell cycle, participating vasifaction in tumor. It occupys mRNA and protein level excessive expression in gastric cancer, and it may make effect on the invasion and metastasis in cancer and it is a molecule index that detects micrometastasis of gastric cancer. Survivin is close correlated with chemotherapy drug resistance of cancer cells. This article summaries Survivin effect on pathogenesy and the advancement in research of the diagnose and treatment in gastric cancer.
出处
《中华肿瘤防治杂志》
CAS
2008年第3期223-226,共4页
Chinese Journal of Cancer Prevention and Treatment
关键词
胃肿瘤
基因表达
凋亡
进展
stomach cancer
Survivin
apoptosis
development
