摘要
目的探讨重症肝炎患者血浆置换(plasma exchange,PE)前后肝功能、凝血指标的变化特征及意义。方法20例重症肝炎患者先后行血浆置换40次,于治疗前后分别取血检测肝功能〔肝功能总胆红素(TBIL)、直接胆红素(DBIL)、天门冬氨酸氨基转移酶(AS)、丙氨酸氨基转移酶(ALT)〕、凝血酶原时间(PT)、凝血酶原活动度(PTA)、血电解质(K+、Na+、Cl-)、血常规(RBC、WBC、PLT),比较肝衰竭经PE治疗前后的效果。结果PE治疗后肝功能TBIL、DBIL、AS、ALT均明显降低,差异有统计学意义(P<0.05);PT明显缩短,差异有统计学意义(P<0.05);PTA明显回升,差异有统计学意义(P<0.05);电解质和血常规前后差异无统计学意义(P>0.05)。PE治疗好转15例,死亡5例。结论血浆置换术是治疗重症肝炎的有效方法,能改善肝功能,缩短凝血酶原时间。
Objective To evaluate the influence and significance of plasma exchange（PE） on liver function indices and blood clotting indices in the patients with liver failure. Methods Twenty patients with liver failure were performed plasma exchange about 40 times one after another. Liver function indices （TBIL, DBIL, AST, ALT）, prothrombin time （PT）, prothrombin activity （PTA）, blood electrolyte（K^＋ , Na^＋ , Cl^- ）, blood routine（RBC, WBC, PLT） were recorded or detected before and after treatment, and the effects of PE on patients with liver failure. Results After PE treatment,liver function indices： total bilirubin（TBIL） ,direct bilirubin（DBIL）, aspartate aminotransferase（AST）,alanine aminotransferase（ALT） obviously decreased and had significant difference（P〈0.05） ,PT obviously shortened（P〈0. 05） ,PTA obviously increased（P〈0.05）. Before and after treatment,electrolyte and blood routine had no significant difference（P〉0.05）. With PE treatment, fifteen patients were improved and five patients died. Conclusion Plasma exchange is an effective method to the patients with liver failure, It can improve liver function indices, and shorten prothrombin time.
出处
《重庆医学》
CAS
CSCD
2008年第6期630-631,共2页
Chongqing medicine
关键词
血浆置换
重症肝炎
肝功能
凝血指标
plasma exchange
liver failure
liver function
blood clotting indices
