摘要
目的:探讨糖尿病对牙槽骨骨质的影响,分析转化生长因子-β1(transform growth factor-β1,TGF-β1)和肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)在其中起的作用。方法:制作糖尿病大鼠模型,检测其牙槽骨骨密度,应用RT-PCR技术检测大鼠牙槽骨中TGF-β1和TNF-α mRNA表达。结果:糖尿病组大鼠牙槽骨较正常组骨质疏松,糖尿病组大鼠牙槽骨TGF-β1和TNF-α mRNA表达明显高于正常组。结论:糖尿病大鼠有牙槽骨骨质疏松倾向,而TGF-β1和TNF-α可能参与牙槽骨骨质疏松的发生与发展。
Objective：To study the correlation between bone density and mRNA expressions of TGF-β1 and TNF-α in the alveolar bones of experimental diabetic rats.Methods：Twenty SD rats were randomly divided into normal group and diabetic group（diabetic model）.After 8 weeks of study,mRNA expressions of TGF-β1 and TNF-α in the alveolar bone were measured by quantitative reverse transcription polymerase chain reaction（RT-PCR） respectively.Bone density and pathology of the alveolar bones were also examined.Results：In diabetic rats group,the alveolar bone density was decreased,and mRNA expressions of TGF-β1 and TNF-α in the alveolar bone were increased greatly.Conclusion：It is suggested that the alveolar bone with diabetes mellitus have a tendency to develop osteoporosis.It may be related with increased expression of TGF-β1 and TNF-α.
出处
《实用口腔医学杂志》
CAS
CSCD
北大核心
2008年第2期165-168,共4页
Journal of Practical Stomatology
