摘要
目的初步探讨血清犬尿喹啉酸（KYNA）含量及犬尿喹啉酸／色氨酸（TRP）比值（KA／T）在精神分裂症患者抗精神药物治疗中的意义。方法测定并比较了健康对照组、初始发病未用药SCH患者（SCHI组）、坚持用药SCH患者（SCHⅡ组）血清KYNA、TRP含量及KA／T值。结果与健康对照组血清KYNA（23．30±8．31）μmol/L、TRP（47．59±10．43）μmol/L比较，SCHI组患者血清KYNA（29．47±12．01）μmol/L和TRP（54．50±9．56）μmol/L含量均升高；SCHII组血清KYNA含量及KA／T比值下降。结论抗精神药物治疗可能使血清KYNA含量和KA／T比值降低。
Objective To explore the clinical significance of serum value of kynurenic acid（KYNA） and KYNA/tryptophan （TRP） ratio （KA/T） in patients with schizophrenia（SCH）. Methods The SCH patients （ n =73） were divided into two groups （drug-naive, first episode patients, patients undergoing antipsychotic treatment） and the concentrations of serum KYNA, TRP in the Sch and health control（ n= 108） were measured. Resuits Compared with healthy control, there were significantly increased concentrations of serum KYNA and TRP in the drug-naive, first episode patients, and the serum KYNA and KA/T ratio were significantly decreased in patients undergoing antipsychotic treatment. Conclusion It showed that antipsychotic treatment may decrease the concentration of KYNA and value of KA/T.
出处
《中国行为医学科学》
CSCD
2008年第3期227-228,共2页
Chinese Journal of Behavioral Medical Science
基金
湖南省医药卫生科研计划课题资助项目（C2005019）
湖南省科技计划项目课题资助项目（05sk3026）
关键词
高效液相色谱法
犬尿喹啉酸
色氨酸
精神分裂症
High performance liquid chromatography
Kynurenic acid
Tryptophan
Schizophrenia
