摘要
目的:比较双频共焦模式和单频模式高强度聚焦超声(HIFU)单次辐照毁损灶的大小。方法:分别采用相同声强度的双频共焦HIFU与传统单频HIFU对透明仿组织体模进行不同时间长度的辐照,直接在透明的仿组织体模上测量HIFU毁损灶的长度和直径。结果:双频和单频模式下,随辐照时间的延长毁损灶逐渐增大;相同声强相同辐照时间下,双频HIFU产生的毁损灶显著大于单频模式所致毁损灶。结论:双频共焦模式可以增大HIFU单次辐照毁损灶的体积,为HI-FU治疗效率的提高提供了一种新技术。
Objective： To evaluate the lesions size created by confocal dual-frequency high-intensity focused ultrasound （HIFU） and conventional single-frequency HIFU. Methods： Confocal dual-frequency mode and single frequency mode HIFU were used to generate ablation lesion under the same spatially averaged intensity level with different different exposure time. Optically transparent tissue mimicking phantom were used as the target of H/FU ablation. The dimensions of HIFU lesions were directly measured on optically transparent tissue mimicking phantoms. Results： The sizes of HIFU lesions enlarged gradually with the in- crease of exposure in both dual-frequency and single-frequency modes at the same spatially averaged intensity level, but the di- mensions of lesions generated by dual-frequency mode were obviously larger than those in single-frequency mode. Conclusions： The confocal dual-frequency HIFU can enhance tissue damaging effects, representing a new technique to improve the ablation efficiency of HIFU.
出处
《中国医学物理学杂志》
CSCD
2008年第2期613-617,共5页
Chinese Journal of Medical Physics
关键词
高强度聚焦超声
超声
仿组织体模
双频
HIFU ultrasound
tissue- mimicking phantom
dual-frequency
lesion
