针刺预处理对心肌缺血模型大鼠CK、CK-MB影响的研究被引量：15

下载PDF

导出

摘要目的:观察针刺预处理对盐酸异丙肾上腺素所致的大鼠缺血心肌的保护作用。方法:将30只大鼠随机分为3组:空白组、模型组、电针治疗组,空白组和模型组每日灌服生理盐水10ml//kg,针灸治疗组针双心俞穴,通电,连续波,频率120Hz/min,20min,日1次,治疗10日。末次治疗结束30min后,将大鼠麻醉后腹部多点注射盐酸异丙肾上腺素复制急性心肌缺血模型。将造模成功的大鼠,于造模后不同时间点监测心电图,标测波J点;造模6h后取血测血清CK(心肌肌酸激酶)、CK-MB(心肌肌酸激酶同功酶)。结果:电针治疗组可使心肌缺血后升高的血清CK、CK-MB减低。结论:针刺预处理对盐酸异丙肾上腺素所致大鼠急性心肌缺血损伤具有良好的保护作用,为针灸抗心肌缺血损伤提供思路。

作者宋春华孙景明王聃红

机构地区黑龙江中医药大学附属二院长春中医药大学

出处《针灸临床杂志》 2008年第1期39-40,共2页 Journal of Clinical Acupuncture and Moxibustion

关键词针刺预处理心肌缺血机理研究

分类号 R245-0 [医药卫生—针灸推拿学]

引文网络
相关文献

参考文献12

1Sylvia P. Ginkgo biloba extract preteatment limits free radicalsoxidative stress in patients undergoing coronary bypassurgery[J] .Cardiovas Drugs Therapy, 1997, 11(2) : 121 - 126 被引量：1
2刘杰,高秀梅,王怡,张伯礼.三七总皂苷对心肌缺血大鼠血流动力学影响实验研究[J].天津中医药,2005,22(2):158-160. 被引量：27
3林荣,郭继鸿主编..心血管疾病的现代观点[M].北京:北京大学医学出版社,2005:779.
4Krajewski S, Krajewska M, Reed JC. Immunhistochemical analysis of in vivo patterns of Bak expression, a proapoptotic member of the Bci - 2 protein family[J]. Cancer Res, 1996,56(12) :2849 - 2855 被引量：1
5Fitch ME, Orang CM, Parslow TG. The BH3 domain is required for caspase - independent cell death induced by Box and oligomycin[ J ]. Cell Death Differ,2000,7(4) :338 - 349 被引量：1
6辛华雯.细胞凋亡的分子调节与肿瘤基因治疗策略[J].医学综述,2001,7(5):263-264. 被引量：4
7Sharov VG, Sabbah NH, Shimoyama H, et al. Evidence of cardiocyte apoptosis in myocardium of dogs with chronic heart failure[J] .Am J Pathol, 1996,148(1 ) : 141 - 149 被引量：1
8Saraste A, Pulkki K, Kallajoki M, et al. Apoptosis in human acute myocardial infarction[J]. Circulation,2007,95(2) :320 - 323 被引量：1
9Fliss H, Gattinger D. Apoptosis in ischemic and reperfused rat myccardium. Circ Rcs,2006,79(5) :949 - 956 被引量：1
10RONA G, CHAPPEL CI, BALAZS T, et al. An infarct - like my - ocardial lesion and other toxic manifestations produced by isopro - terenol in the rat[J]. AMA Arch Pathol, 1959,67(4):443- 455 被引量：1

二级参考文献18

1[1]Kerr JFR, Wyllie AH, Currie AR. Apoptosis: a basic biological phenome-non with wide-ranging implication in tissue kinetics. Br J Cancer, 1972,26: 239 被引量：1
2[2]Tsujimoto Y,Gorhan J,Cossman J,et al. The t(14;18)chromosome trans-locations involved in B-cell neoplasms result from mistakes in VDJ join-ing. Science, 1985,229:1390 被引量：1
3[3]Kirshenbaum LA, de Moissac D. The Bcl-2 gene product prevents pro-grammed cell death of ventricular myocytes. Circulation 1997,96 (5):1580 被引量：1
4[4]Blagosklonny MV,Schulte T,Nguyen P,et al. Taxol-induced apoptosis andphosphorylation of Bcl-2 protein involves C-Raf-1 and represents a woveC-Ra-1 signal tranduction pathway. Cancer Res, 1996,56:1851 被引量：1
5[5]Harnois DM, Que FG, Celli A,et al. Bcl-2 is overexpressed and alters thethreshold for apoptosis in a cholangiocarcinoma cell line. Hepatology,1997,26(4) :884 被引量：1
6[6]Thomas A, ELRouby S, Reed JC, et al. Drug-induced apoptosis in B-cellchronic lymphocytic leukemia: relationship between p53 gene and Bcl-2/bax proteins in drug resistance. Oncogene, 1996,12:1055 被引量：1
7[7]Pepper C, Hoy T, Bentley-DP, et al. Bcl-2/Bax ratios in chronic lympho-cytic leukemia and their correlation with in vitro apoptosis and clinical re-sistance. Br J cancer, 1997,76(7): 935 被引量：1
8[8]Sach L, Lateon J. Controls of programmed cell death in normal and leuke-mia cells: New implication for therapy. Blood, 1993,82:15 被引量：1
9[9]EL-Deiry WS,Harper JW,O'Connor PM,et al. WAF1/CIPI is induced inp53-mediated G1 arrest and apoptosis. Cancer Res, 1994,54:1169 被引量：1
10[10]Rasbridge SA,Gillett CE,Seymour AM,et al. The effects of chemotherapy on morphology, cellular proliferation, apoptosis and oncoprotein expression in primary breast carcinoma. Br J Cancer, 1994,70: 335 被引量：1