摘要
目的探讨惰性气体再呼吸法检测运动心排血量（cardiac output，CO）和左室射血分数（left ventricular ejection fraction，LVEF）、6min步行试验（six-minute walk test，6MWT）距离评估慢性心力衰竭（chronic heart failure，CHF）患者心功能的意义。方法检测36例CHF患者（CHF组）LVEF，并行6MWT，于试验前后利用惰性气体再呼吸法检测CO，同时与健康受试者（对照组）比较。结果6MWT试验距离CHF组（333．00±49．64）m，较对照组（582．56±67．97）m明显减低（P〈0．01），NYHA心功能Ⅲ级（314．82±36．27）m，较Ⅱ级（361．57±55．42）m明显减低（P〈0．05）。CHF组的LVEF为（47．0±0．4）％，较对照组（66．9±5．2）％明显减低（P〈0．01）；NYHA心功能Ⅲ级为（43．3±10．3）％，较Ⅱ级（52．8±7．6）％明显减低（P〈0．01）。运动CO增加值CHF组为（5．97±1．89）L／min，较对照组（8．88±0．52）L／min明显减低（P〈0．01）；NYHAⅢ级为（5．31±1．52）L／min，较Ⅱ级（7．01±1．98）L／rain明显减低（P〈0．01）。6MWT距离与运动CO呈正相关（r=0．63，P〈0．01），但LVEF和运动CO无相关性（r=0．11，P〉0．05）。结论惰性气体再呼吸法检测运动心排血量具有无创、安全、简便、准确的特点,能与6MWT共同评估CHF患者心脏储备功能。
Objective To evaluate the significance of cardiac output （CO） response against exercise determined by IGR method and LVEF, 6 MWT distance in patients with chronic heart failure （CHF）. Method To adopt 6 MWT, and before and after the test measuring the CO by the ｜GR method, furthermore, measure LVEF to 36 patients（ heart failure group） with CHF, compare with the health groups （ control group）. Results The 6MWT distance of heart failure group （ 333.00 ± 49.64 ） m decrease compared with the control group （582.56 ±67.97） m （ P 〈 0.01 ）, moreover, the distance of NYHA class Ⅲ （314.82 ±36.27）m is significantly shorter than Ⅱ （361.57 ±55.42）m （P 〈0.05）. The LVEF of heart failure group （47.0 ± 0.4） % reduce compared with the control group （66.9 ± 5.2 ） % （ P 〈 0.01 ）, and the data of NYHA class Ⅲ （43.3 ± 10.3 ） % is significantly lower than Ⅱ （ 52.8 ± 7.6） % （ P 〈 0.01 ）o The increase in CO response against exercise of heart failure group （5.97 ± 1.89 ） L/min decrease compared with control group （8.88 ± 0.52 ） L/min （ P 〈 0.01 ）, furthermore, the value of NYHA class Ⅲ （5.31 ±1.52） L/min, compared with Ⅱ （7.01 ± 1.98 ） L/min, is obviously lower（ P 〈 0.01 ）. The 6MWT distance correlates positively with the increase in CO response against exercise （ r = 0.63, P 〈 0.01 ）, but the correlation is not found between the increase CO response against exercise and the LVEF （r = 0.11 ,P 〉 0.05）. Conclusion Our results show that CO response against exercise measured by IGR method, with the advantages of being noninvasive, safe, convenient and accurate, combining with the 6MWT can evaluate cardiac reserve in patient with CHF.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
2008年第3期236-239,共4页
Chinese Journal of Cardiology
关键词
心力衰竭
充血性
心脏功能试验
诊断技术
心血管
Heart failure, congestive
Heart function tests
Diagnostic techniques, cardiovascular
