摘要
目的强调孕妇泌尿生殖道感染无乳链球菌的危害性,分析该组无乳链球菌对7种常用抗菌药物的药敏情况,并提出预防措施,以引起临床重视并指导临床用药。方法112株菌触酶试验阴性,马尿酸试验阳性,CAMP试验阳性,并用API20STREP验证确实为无乳链球菌。采用K-B法测定无乳链球菌对7种抗菌药物的敏感性。结果所有无乳链球菌对青霉素、头孢唑啉、头孢曲松、万古霉素均敏感;对红霉素、克林霉素、左氧氟沙星敏感率分别为:39.3%、56.2%、74.1%。其中红霉素的耐药率高达49.1%,其次克林霉素为41.1%。结论孕妇无乳链球菌感染的治疗及预防用药首选青霉素、氨苄青霉素;对低危险性青霉素过敏可选用头孢唑啉;对青霉素过敏的高危险者应根据药敏结果选用红霉素或克林霉素。临床医生重视孕妇无乳链球菌的检测可有效预防其危害性。实验室常规准确报告无乳链球菌药敏结果,对临床医生合理用药治疗无乳链球菌感染具有重要指导意义。
Objective To emphasize the hazardness due to streptococcus agalactiae infecting genitourinary tract of the pregnant women, and to analyze the drug resistance to 7 kinds of antibiotics in streptococcus agalactiaes in order to guide the clinical drug usage. Methods 112 isolates of streptococcus agalactiaes were identified by API 20 STREP. The susceptibility to 7 kinds of antibiotics were performed by K - B method. Results All of the 112 strains were susceptible to penicillin, cefazolin, ceftriaxone, vancomycin. The susceptibility to erythromycin, clindamycin and levofloxacin were 39.3% , 56.2% , 74.1% respectively. The resistance ratio to erythromycin was 49.1% followed by clindamycin （41.1% ）. Conclusions Penicillin and ampicillin were the first recommended antibiotics in treating and preventing streptococcus agalactiae infection. Erythromycin and clindamycin could be selected according to antibiotic susceptibility results in case of the patient with severe penicillin allergy. It is important to detect streptococcus agalactiae in preventing its infection among pregnant women. The results of the antibiotic susceptibility test can guide the rational drug usage in clinical treatment of streptococcus agalactiae infection.
出处
《医学研究杂志》
2008年第3期88-89,共2页
Journal of Medical Research
关键词
无乳链球菌
抗菌药物
耐药性
Streptococcus agalactiae
Antibiotics
Drug resistance
