摘要
目的研究新生霉素的结构单元诺维糖和香豆素的抗肿瘤活性。方法合成新生霉素的结构单元3-O-氨基甲酰基诺维糖(化合物2)和3-乙酰氨基-7-羟基香豆素(化合物3),MTT法测定两化合物与新生霉素抗K562细胞的活性。结果化合物2的IC50为2.287mmol,化合物3的IC50为2.165mmol,新生霉素的IC50为0.350mmol。结论化合物2和化合物3具有抗肿瘤活性,但比新生霉素弱。
Objective To study the antitumor activity of noviose and coumarin in novobiocin. Methods Synthesis 3-O-carbamylnoviose and 3-acetamido-7-hydroxycoumarin, compare the activity of inhibit K562 cell with novobiocin by MTT. Results The half maximal inhibitory concentration（IC50）： compound 2 was 2. 287 mmol/L, compound 3 was 2. 165 mmol/L, novobiocin was 0. 350 mmol/L. Conclusion Noviose and coumarin have a little antitumor activity but it is weaker than novobiocin.
出处
《福建医科大学学报》
2008年第1期36-38,共3页
Journal of Fujian Medical University
基金
福建省自然科学基金资助项目(2006J0252)
