摘要
设计并合成了10个新的6-取代苯氧基-7-氯-4-羟基-3-喹啉羧酸乙酯类化合物;合成路线短,产率高,原料易得,易实现工业化;所有化合物的结构均经1HNMR,MS,IR和元素分析所证实;并选择了其中7个化合物进行抗球虫活性实验,结果表明:其中4个6-取代苯氧基-7-氯-4-羟基-3-喹啉羧酸乙酯化合物具有抗球虫效果,并有可能作为抗球虫药物使用.
Ten ethyl 6-（substituted phenoxy）-7-chloro-4-hydroxy-3-quinolinecarboxylates have been designed and synthesized. The new process has the advantages of high yield and cheap raw materials, which, thus, is convenient for the commercial production. Structures of the new compounds have been confirmed by 1H NMR, MS, IR spectra and elemental analysis. Seven of the new compounds were chosen for the anticoccidial activity test and the result has shown that four of them have anticoccidial activity
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2008年第3期432-435,共4页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.20372052)资助项目
