摘要
该文就目前以分子模拟为手段的紫杉醇类分子的定量结构-抗癌活性关系研究进行了综述。主要围绕该类分子结构的关键活性基团,即C13侧链、C14、C2、C10位基团及四元氧环对活性的贡献进行论述,总结了目前此类研究达成的共识及争议。此外,对结构之外的其他活性影响因素及活性分类研究也进行了汇总。
The up-to-date quantitative structure-antitumor activity relationship studies of taxol analogues based on molecular model- ing techniques were reviewed in the present paper. Both the common understandings and the debates about the contributions of several key structural groups, including the C13 side chain, the substituents of C14, C2 and CIO as well as the oxtane ring to the biological activities of taxol derivatives were summerized. In addition, the studies about other factors influencing the activity except for the structure and the classification research of the mol- ecules were also discussed.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2008年第3期288-293,共6页
Chinese Pharmacological Bulletin
基金
大连理工大学青年教师培养基金资助课题(No1000-893231)
大连理工大学博士科研启动基金资助课题(No1000-893361)
