摘要
目的观察盐酸丁丙诺啡对全身麻醉苏醒拔管期机体应激反应的影响。方法60例ASAⅠ～Ⅱ级择期全麻下剖腹手术患者,随机分为三组,每组20例,对照组(C组)注射生理盐水;盐酸丁丙诺啡3μg/kg组(B3组)缝皮前静脉注射3μg/kg盐酸丁丙诺啡;盐酸丁丙诺啡6μg/kg组(B6组)缝皮前静脉注射盐酸丁丙诺啡6μg/kg。所有患者均给予异丙酚、维库溴胺、芬太尼作为全麻诱导用药,气管插管后及手术中微泵持续静脉注射异丙酚,间断静脉注射维库溴胺维持全麻及肌松。分别于术前、拔管时和拔管后5min测量血压、心率和呼吸及血氧饱和度;并对血压、呼吸、患者清醒程度、肢体运动进行评估。记录拔管时躁动的发生率及清醒时的拔管时间。结果C组血液动力学受影响较大,拔管时SBP和HR与术前比较有非常显著升高(P<0.01);盐酸丁丙诺啡B3组和B6组血液动力学较平稳,SBP、HR和SPO2与术前比较无显著性差异(P>0.05)。拔管后5min各组各项指标基本恢复到术前水平。结论盐酸丁丙诺啡能减轻全身麻醉苏醒拔管期机体应激反应,盐酸丁丙诺啡3μg/kg静脉注射即能很好的抑制应激反应。
Objective To observe the impact of intravenous buprenorphine on stress response induced by tracheal extubation. Methods The 60 cases of ASA Ⅰ -Ⅱ patients, which were scheduled for selective surgery of abdomen were randomly divided into three groups and received a standard general anesthesia consisting of fentanyl,propofol,vercuronium and isoflurane. After the operation, buprenorphine 3μ g/kg （Group B3）, buprenorphine 3μg/kg （Group B6）,the normal saline （Group C） were given respectively by intravenousy injection,postoperative tracheal extubation was performed when acceptable criteria was achieved. Non-invasive arterial pressure （SBP）,heart rate （HR） and SPO2 were recorded before operation,as well when tracheal extubation and 5min after extubation. Results Group C was more increased when extubation than before operation in SBP, HR （P〈0.01）; In Group B3 and Group B6, SBP, HR and SPO2 were no significant variation （P〉0.05）. Of GroupC,B3 and B6, in all parameters there were no significant variat_;ons between before operation and 5min after extubation（P〉0.05）. Conclusion Intravenous injection of buprenorphine 3μg/kg can effectively relieve stress response inducde by tracheal extubation.
出处
《实用医药杂志》
2008年第3期270-272,共3页
Practical Journal of Medicine & Pharmacy
关键词
盐酸丁丙诺啡
气管拔管
应激反应
Buprenorphine Tracheal extubation Stress response
