摘要
目的探讨环丙孕酮(达英-35)和螺内酯对多囊卵巢综合征(PCOS)不孕预处理的作用。方法PCOS患者130例,随机分为治疗组和对照组各65例。两组均行促排卵治疗。治疗组同时给予环丙孕酮和螺内酯各20 mg,每日两次联合预处理3个月,治疗前后测定促卵泡激素(FSH)、促黄体生成激素(LH)、雌二醇(E2)、催乳素(PRL)、睾酮(T)等变化。结果治疗组LH水平明显降低,LH/FSH值正常,差异有极显著性(P<0.01);排卵率和妊娠率均高于对照组(P<0.01)。结论环丙孕酮联合螺内酯预处理PCOS患者,可提高促排卵的疗效和妊娠率。
Objective To investigate the effect of spironolactone and cyproterone （diane-35） in female patients with polycystic ovary syndrome （PCOS）. Methods 130 PCOS patients were randomly divided into two groups： treat group with pironolaetone combined with cyproterone and control group with placebo twice per day for 3 months. The levels of sexual hormones during preor pro-treatment, including FSH,LH, E2 ,PRL,T were analyzed in two groups. Results After three months of the treatment of spironolaetone plus cyproterone , the ratio of luteinizing hormone （LH） and follicle stimulating hormone（FSH）,The levels of LH were significantly decreased （P〈0.01）. Both ovulation rate and pregnancy rate increased significantly in treatment group. Conclusion The combined cyproterone and spironolactone could strongly promote the ovulation and increase the pregnancy frequenee in PCOS patients.
出处
《医药导报》
CAS
2008年第3期294-295,共2页
Herald of Medicine
