摘要
目的观察黄芪扶正饮治疗复发性生殖器疱疹(recurrent genital herpes,RGH)的临床疗效及其对患者外周血相关细胞因子(IL-4、IL-10、IL-12、IL-18)的影响。方法将84例RGH患者随机分成3组,分别用黄芪扶正饮(治疗组,31例)、阿昔洛韦(对照1组,25例)和阿昔洛韦联合干扰素(对照2组,28例),但3组局部皮损均用聚维酮碘溶液治疗,疗程均为4周,6个月后统计复发情况,并用双抗体夹心ELISA法检测3组患者治疗前后外周血细胞因子水平。结果3组患者均痊愈,但治疗组6个月后复发10例,对照2组复发6例,明显低于对照1组(复发18例,P<0.01),治疗组与对照2组比较差异无统计学意义。与健康人比较,治疗前3组患者IL-4、IL-10含量升高,IL-12、IL-18含量降低(P<0.01);治疗后治疗组和对照2组IL-4、IL-10含量下降,IL-12、IL-18含量上升(P<0.05或P<0.01),且下降或上升幅度优于对照1组(P<0.01)。结论黄芪扶正饮能降低RGH的复发率,无明显的不良反应,并能调节机体免疫功能。
Objective To observe the clinical efficacy of Huangqi Fuzheng Decoction （HQFZD） in treating recurrent genital herpes （RGH） and its influence on related cytokines in peripheral blood. Methods Eighty-four patients with RGH were randomly assigned to 3 groups, the treated group treated with HQFZD （31 cases）, the control group A （25 cases） treated with Aciclovir, and the control group B （28 cases） treated with Aciclovir plus interferon. The course of treatment was 3 weeks for all. The relapse rate was estimated at 6 months after treatment, and levels of IL-4, IL-10, IL-12 and IL-18 in all patients were detected before and after treatment using doublesandwich ELISA. Results All patients were cured after treatment. The relapse rate in the treated group and the control group B was lower than that in the control group A （ P 〈 0. 01 ） but insignificant difference was shown between the former two groups. Before treatment, patients＇ serum levels of IL-4 and IL-10 were significantly higher while those of IL-12 and IL-18 were lower than the normal range （P 〈 0. 01 ）. The abnormal change aforementioned reversed after treatment in the treated group and the control group B （P 〈0. 05 or P 〈0. 01 ）, showing a superior effect to that in the control group A （ P 〈 0. 01 ）. Conclusion HQFZD can reduce the relapse rate of RGH without obvious adverse reaction, and it could also enhance the immunity of the patients.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2008年第3期222-224,共3页
Chinese Journal of Integrated Traditional and Western Medicine
