摘要
目的观察青黄散加补肾健脾中药治疗骨髓增生异常综合征(MDS)的临床疗效。方法55例MDS患者给予青黄散、补肾健睥汤药及雄性激素等治疗。结果55例MDS患者中,完全缓解11例(20.0%),总有效41例(74.5%)。根据FAB分型,RA/RAS型34例,完全缓解9例(26.5%),总有效28例(82.4%);RAEB型21例,完全缓解2例(9.5%),总有效13例(61.9%),两型间疗效比较差异无统计学意义。按国际预后积分系统(IPSS)评定标准,中危Ⅰ组36例,有效25例(其中完全缓解10例),无效11例。中危Ⅱ组7例,完全缓解1例,有效4例,无效2例。高危组6例,完全缓解0例,有效3例,无效3例。3组疗效比较差异无统计学意义。有效者41例,治疗后白细胞、血红蛋白和血小板计数均较治疗前升高(P<0.05);染色体异常组16例,有效11例(68.8%);染色体正常组33例,有效24例(72.7%);染色体异常与否间疗效比较,差异无统计学意义。结论化瘀补肾为主综合治疗MDS具有确切的临床疗效,疗效与FAB分型、IPSS积分及染色体异常与否无明显相关性。
Objective To observe the clinical efficacy of Qinghuang Powder combined with Chinese herbs for reinforcing Shen and strenghening Pi in treating myelodysplastic syndrome （MDS）. Methods Fifty-five patients with diagnosis fitting to MDS were treated with Qinghuang Powder and decoction for strengthening Pi and reinforcing Shen, in combination with Stanozololum. Results Eleven patients （20. 0% ） out of the 55 were completely remitted （CR）, the total effective rate being 74.5% （41/55 cases）. By FAB typing, 9 （26.5%） in the 34 patients of type RA/RAS were CR, with the total effective rate of 82.4% （28/34 cases）, and in the 21 patients of type RAEB, 9.5% （2/21 cases） were CR with the total effective rate of 61.9% （13/21 cases）, showing insignificant statistical difference between the two types （ P 〉 0. 05 ）. By international prognostic scoring system （ IPSS）, the treatment was evaluated as CR in 10 patients, effective in 25 and ineffective in 11 in 36 patients of moderate risk group Ⅰ , the responding numbers were 1,4, 2 in 7 patients of moderate risk group Ⅱ and O, 3, 3 in 6 patients of high risk group, respectively, also showing insignificant difference between groups （ P 〉 0. 05 ）. Levels of Hb, WBC and platelet significantly increased after treatment （P 〈0. 05 ）. By cytogenetics, the effective rate was 68.8% （11/16 cases） in patients with abnormal chromosome and 72.7% （24/33 cases） in those with normal chromosome, with insignificant difference （P 〉 0. 05 ）. Conclusion The comprehensive therapy with TCM treatment for reinforcing Shen and dissolving stasis in dominance has a definite clinical effect in treating MDS, it was not significantly associated with FAB typing, IPSS score, and chromosome abnormality of patients.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2008年第3期216-218,共3页
Chinese Journal of Integrated Traditional and Western Medicine
基金
国家自然科学基金(No.30572450)
关键词
骨髓增生异常综合征
青黄散
补肾健脾中药
中西医综合治疗
临床疗效
myelodysplastic syndrome
Qinghuang Powder
Chinese herbs for reinforcing Shen and strenghening Pi
comprehensive TCM and Western medical therapy
clinical efficacy
