摘要
目的探讨中药芪参活血颗粒在重度脓毒症治疗中的抗炎作用及临床疗效。方法选择北京地区4家医院167例重度脓毒症患者,随机分为两组,分别给予西药常规(西药组,85例)和芪参活血颗粒加西药常规(中西医组,82例)治疗,分析比较两组患者炎症细胞因子(IL-6、IL-10、TNF-α)、降钙素原(PCT)、Marshall评分、APACHEⅡ评分、住ICC时间及28天病死率的情况。结果中西医组治疗第5天及第10天TNF-α、IL-6水平较西药组明显下降(P<0.05),住ICU时间明显缩短(P<0.05),28天病死率明显下降(P<0.05),且服药期间无严重的不良事件发生。结论中西医结合治疗脓毒症可显著降低TNF-α、IL-6水平,缩短住ICC时间,降低病死率,在脓毒症治疗方面显示了较好的治疗前景。
Objective To study the anti-inflammatory effect and the therapeutic efficacy of Qishen Huoxue Granule （QHG） in treating severe sepsis. Methods One hundred and sixty-seven patients with severe sepsis were enrolled and randomly assigned to two groups, the 85 patients in the control group treated with conventional Western medicine and the 82 in the QHG group treated with conventional Western medicine plus QHG. Changes of tumor necrosis factor α （TNF-α）, interleukin-6 （IL-6）, interleukin-10 （IL-10）, procalcitonin （PCT）, Marshall score, APACHE Ⅱ score, ICU stay time and 28-day mortality were monitored and compared. Results Compared with the control group, IL-6 and TNF-α levels, the ICU stay time and 28-day mortality were significantly lower in the QHG group （all P 〈 0.05 ）. During the QHG treatment, no severe adverse event was observed. Conclusion The integrative treatment could reduce the blood levels of IL-6 and TNF-α, shorten the ICU stay time and decrease the 28-day mortality of patients with sepsis, showing a favor therapeutic prospect.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2008年第3期209-211,共3页
Chinese Journal of Integrated Traditional and Western Medicine
基金
北京市科委重大项目“MODS中西医结合诊治降低病死率的研究”(No．京科计发2002-641)
