摘要
目的评价广州市不同地区10岁以下儿童乙型肝炎疫苗免疫效果。方法对本市老城区、新城区和农村1995～2005年出生、接受乙型肝炎疫苗全程免疫的儿童，按分层随机抽样3890人，检测其HBsAg和抗-HBs水平，并计算阳性率。结果1995—2005年，三地区出生的儿童毗阳性率逐年下降，抗．HBs阳性率逐年上升；老城区HBsAg阳性率比新城区和农村明显下降，老城区和新城区抗-HBs阳性率比农村明显上升；三地区10、5、0岁儿童HBsAg阳性率依次下降，抗-HBs阳性率依次上升。结论广州市10岁以下儿童乙肝疫苗免疫保持在高水平，农村的乙肝疫苗免疫效果较老城区和新城区偏低，可能是造成乙型肝炎发病率高的主要原因之一。
Objective To evaluate the immune effect of hepatitis B （liB） vaccine in children born in 1995 - 2005 in various districts of Guangzhou City, China. Methods A total of 3890 children bern in 1995 - 2005 in Guangzhou City, immunized with 3 doses of HB vaccine according to the immunization schedule, were selected randomly for determination of serum HBsAg and anti-HBs and calculation of the corresponding positive rates. Results The positive rate of serum HBsAg of children bern in 1995 - 2005 decreased,whih that of serum anti-HBs increased year by year. The HBsAg positive rate of children in old urban district was significantly lower than those in new urban and rural districts. The anti-HBs positive rates of children in old and new urban districts were significantly higher than that in rural districts. The determination results of children bern in 1995,2000 and 2005 proved that the HBsAg positive rate in various districts decxeased while anti-HBs positive rate increased with the decreasing age. Conclusion HB vaccine showed good immune effect on the children bern in 1995 - 2005 in Guangzhou City.The high morbidity of HB in rural district might be due to the low anti-HBs positive rate as compared with those in old and new urban districts.
出处
《中国生物制品学杂志》
CAS
CSCD
2008年第3期235-236,共2页
Chinese Journal of Biologicals
基金
广州市卫生局立项课题(编号2006YB134)
