摘要
目的:探讨影响全身惊厥性癫癎持续状态(GCSE)治疗效果的相关因素,为临床诊治提供理论依据。方法:回顾性分析37例GCSE患者的治疗过程。将治疗效果分为显效(完全控制不复发)、有效(发作频率明显减少,症状减轻)和无效(发作频率和症状无明显变化,甚至加重)。对性别、年龄、病因和治疗延迟与治疗效果的关系用Logistic逐步回归,向前逐步法进行多因素分析。结果:性别(OR=12.798,95%CI:3.329￣49.199)、年龄(OR=0.784,95%CI:0.681￣0.902)、病因(OR=5.958,95%CI:2.324￣7.750)和治疗延迟的时间(OR=1.153,95%CI:1.034￣1.286)是影响GCSE治疗效果的因素。结论:GCSE早期治疗是预防发作时间的延长和复发,改善治疗效果的重要环节。
Aim： To investigate the factors associating with treatment outcome of 37 generalized convulsive status epilepticus （GCSE） patients, so as to provide theoretical basis for clinical treatment. Methods： 37 patients with generalized convulsive status epilepticus were retrospectively analyzed. The treatment outcome was rated as excellence （Seizures were fully controlled and had no recurrence）, utility （The frequency of seizures decreased significantly and symptoms were lighter） and inefficacy （The frequency of seizures and symptoms had no change and were even heavier）. Logistic regression analysis was done to analyze the relationship between related indexes and treatment outcome. Results ： Sex （OR=12.798, 95%CI： 3.329 - 49.199）, age （OR =0.784, 95%CI. 0.681 - 0.902）, etiology（OR=5.958, 95%CI： 2.324 - 7.750）and treatment delay （OR= 1.153, 95%CI： 1.034 - 1.286） would influence the treatment outcome of GCSE. Condusion： Early treatment of generalized convulsive status epilepticus is important to preventing seizure prolongation and recurrence so as to improve treatment outcome.
出处
《中国临床神经科学》
2008年第2期130-133,共4页
Chinese Journal of Clinical Neurosciences
基金
教育部留学回国人员科研启动基金资助项目(教外司留[2006]331号)
关键词
全身惊厥性癫痫持续状态
性别
年龄
病因
治疗延迟
治疗效果
generalized convulsive status epilepyicus
sex
age
etiology
treatment delay
treatment outcome
