摘要
本文用同种异体犬长骨骨髓脂肪静脉注射法建立脂肪栓塞综合征动物模型。通过周围静脉血血凝块快速冰冻切片油红０脂肪染色、周围静脉血与肺内血游离脂肪酸测定、股动脉血氧分压分析，并结合脂肪栓塞后４８ｈ犬的肺、脑、心、肾等主要脏器的大体标本观察和病理组织学检查，以探讨其脂肪栓塞综合征的病理变化和发病机制。结果显示脂肪栓塞综合征的主要病变在肺，肺部病变是发生脂肪栓塞综合征的基础。脂滴和血小板在肺内的机械性阻塞和游离脂肪酸的毒性作用，是脂肪栓塞综合征的发病原因。
To observe the pathological changes and probe into the mechanism of fat embolism syndrome(FES), the canine FES animal model was established with the intro venous injection of homologous dog bone marrow fat. The venous blood clot were cut with rapid frozen and stained with oil red “O”, and the blood PaO 2 and serum free fat acid (FFA) were determined periodically. The pathological changes of lung, heart and kidney were observed 48 hours after the FES happened. The results showed: (1)The levels of serum FFA were markedly elevated after the begining of bone marrow injection, especially in pulmonary venous system; (2)The levels of PaO 2 dropped bown obiously; and (3)The pathological changes were mainly in the lungs. Our study suggests that the lung is the foundation of FES, and the most probable etiological factor is the mechanical obstruction of pulmonary vessels due to fat droplets and platelets and the toxic effects of FFA.
出处
《军医进修学院学报》
CAS
1997年第2期105-107,共3页
Academic Journal of Pla Postgraduate Medical School
基金
"八五"军队医药科研基金
