摘要
目的：探讨对氯米芬（CC）抵抗的PCOS患者行腹腔镜下卵巢电灼术（LOD）时，单侧卵巢所负荷电能对患者术后内分泌及其临床疗效的影响。方法：96例氯米芬抵抗PCOS患者按其在LOD术中单侧卵巢上所负荷的电能分成3组，观察术后内分泌的变化及自发性排卵率和妊娠率。结果：3组患者在LOD术后6个月的自发性排卵率和妊娠率比较差异无显著（P〉0．05）。LOD术后，3组患者的LH、T、LH／FSH及卵巢体积均明显的下降，PRL的浓度则无明显的变化，FSH的浓度在LOD前后差异无显著性。结论：LOD是对CC抵抗的PCOS患者有效的治疗方法，用绝缘的针状电极于每侧卵巢上负荷800～1000J的电能时，能够改善高雄激素血症及临床症状，提高生殖预后；再增加卵巢所负荷的电能，并不能明显提高患者的生殖预后，反而增加了术后发生卵巢早衰及卵巢萎缩的风险。
Objective： To determine the optimal amount of thermal energy required for laparoscopic ovarian diathermy （LOD） in women with polycystic ovary syndrome （PCOS）. Methods：96 women with clomiphene-resistant PCOS were dMded into three groups according to the intensity of electricity applied on ovades. Natural ovulation, preganacy rate and changes of hormone were observed.Results：Patients were homogeneous of age, BMI, hormone level and duration of infertility. Ovulation occurred in 59.2%, 57.8%, and61.2% of women in three groups respectively. Pregnancy rate was 35.6%, 34.7%, and 37.0% respectively. LH/FSH, ovarian volume, serum concentrations of total testosterone and LH reduced significantly after LOD, while FSH and PRL had no significant change.Conclusions：The clinical response to LOD is dose-dependent. 800-1000J of electricity on each side of ovary improved hyperandrogenemia, clinical symptom and reproductive prognosis. While higher intensity may cause excessive destruction to the ovary without any improvement in outcome.
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2008年第2期116-118,共3页
Journal of Practical Obstetrics and Gynecology
关键词
腹膣镜下卵巢电灼术
多囊卵巢综合征
电能
内分泌
Laparoscopic ovarian diathermy
Polycystic ovarian syndrome
Thermal energy
Endocrine
