摘要
化疗目前仍然是胰腺癌辅助治疗的重要手段之一，但常用的化疗药物５－氟尿嘧啶（５－ＦＵ），丝裂霉素（ＭＭＣ）是否能够通过胰腺组织，并达到有效治疗浓度，尚不清楚。作者以狗为实验对象，于测定多种抗生素在血液和胰液中浓度比的工作基础上，研究了快速静脉推注５－ＦＵ及ＭＭＣ后血液和胰液中药物分布及相关性，同时对术后有胰支架管的部分胰十二肠切除患者进行了上述观察。结果显示血中５－ＦＵ及ＭＭＣ能够穿透胰腺组织，通过血－胰屏障。作者认为５－ＦＵ和ＭＭＣ可适用于胰腺癌的辅助化疗。
Chemotherapy is one of important adjuvant therapies for patients with pancreatic adenocarcinoma, but the mechamism 5 FU and MMC distributed over the pancreas is not known at home and abroad. Based on determining the ratio of the concentration of several kinds of antibiotic in plasma and pancreatic juice,we used forteen dogs to study the distribution and the relationship of agents in plasma and pancreatic juice after giving 5 FU and MMC intravenously. At the same time,we observed some patients who received Whipple′s operation. The results showed that 5 FU and MMC in plasma can penetrate the pancreatic tissue and cross the blood pancreatic juice barrier (BPJB).Both agents suitable for the adjuvant chemotherapy of pancreatic adenocarcinoma.
出处
《中华外科杂志》
CAS
CSCD
北大核心
1997年第5期302-304,共3页
Chinese Journal of Surgery
基金
高等学校博士学科点专项科研基金
关键词
胰腺肿瘤
药代动力学
氟尿嘧啶
药物疗法
Pancreatic neoplasms Pharmacokinetics Fluorouracil Mitomycins
