摘要
A new copolymer(C) was designed and synthesized.Isothermal Titration Calorimetry(ITC) expe-riments showed the strong binding of C-Zn and the predetermined peptide sequences(DFLAE,appear in many peptides sequence which cumulate in serum of uremic patients).The further ITC experiments demonstrate that the binding is the result of the cooperative effect of coordination and hydrophobic interaction,which may provide further understanding on the mechanism of polymer-metal-peptide interaction and a structural basis for designing the adsorbents for the target peptide.
A new copolymer（C） was designed and synthesized. Isothermal Titration Calorimetry（ITC） experiments showed the strong binding of C-Zn and the predetermined peptide sequences（ DFLAE, appear in many peptides sequence which cumulate in serum of uremic patients）. The further ITC experiments demonstrate that the binding is the result of the cooperative effect of coordination and hydrophobic interaction, which may provide further understanding on the mechanism of polymer-metal-peptide interaction and a structural basis for designing the adsorbents for the target peptide.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2008年第3期658-660,共3页
Chemical Journal of Chinese Universities
基金
国家自然科学基金(批准号:50573034,20634030)资助
关键词
多肽
共聚物
分子间相互作用
Polypeptide
Copolymer
Intermolecular interaction
