摘要
复制衰老最早是在体外培养的3个月人胚肺二倍体细胞中发现的一种细胞状态,它不同于细胞死亡和凋亡,被认为是体内许多年龄相关性疾病的病因。复制衰老与体外培养的细胞衰老改变有密切关系,但复制衰老与眼部组织的关系尚未明了。就复制衰老与角膜、晶状体上皮细胞(LECs)、视网膜色素上皮(RPE)细胞关系的研究进展进行综述。
Replication senescence had been initially discovered as a pattern of in vitro culture of three-month human fetal lung diploid cell strains. It is a pattern of existed cell and is different from cell death or apoptosis. It is reported as a cause of plenty of age-related disease. Many researches revealed that an intimate relationship between replication senescence and cultured senescence cell in vitro, but the relationship between replication senescence and ocular tissue remain underinvestigation. Therefore ,this paper reviewed the latest advance in the research of the replication senescence in cornea, lens epithelium cell, retinal pigment epithelium cells.
出处
《眼科研究》
CSCD
北大核心
2008年第3期234-237,共4页
Chinese Ophthalmic Research
