摘要
重症大疱性药疹，包括重症多形红斑、Stevens-Johnson综合征、中毒性表皮坏死松解症，是皮肤科最严重的疾病之一。近年对其发病的免疫机制有新的认识，主要是在Fas-FasL介导的细胞凋亡、细胞毒T细胞的作用、肿瘤坏死因子-α诱导凋亡及线粒体的损伤方面。在临床治疗中可应用免疫治疗药物，如静脉滴注丙种球蛋白、环孢素、沙利度胺及抗肿瘤坏死因子单克隆抗体等。
Severe bullous drug eruption, including erythema multiforme major, Stevens-Johnson syndrome and toxic epidermal necrolysis, are one of the most severe skin diseases. Some advances have been made in their immunopathogenesis, such as the apoptosis mediated by Fas-FasL and induced by TNF-α , effect of cytotoxic T cells, and mitochondrial damage. Furthermore, these diseases can be managed with immunotherapy, e.g. intravenous immunoglobulin, cyclosporine, thalidomide and anti-TNF monoclonal antibodies.
出处
《国际皮肤性病学杂志》
2008年第2期78-80,共3页
International Journal of Dermatology and Venereology
