摘要
目的研究中晚期慢性肾脏疾病（CKD）患者左心室心肌质量指数（LVMI）与甲状旁腺激素（PTH）、钙磷乘积之间的关系。方法选择81例CKD35期患者作为试验组，30例正常人作为对照组，作心脏超声检查，测量左心室舒张末内径（LVDd）、左心室收缩末期内径（LVDs）、室间隔舒张末厚度（IVS）、左心室后壁舒张末厚度（PWTH）、左心室射血分数（EF），舒张早期和舒张晚期二尖瓣口最大血流速度之比（E／A），用公式计算左心室心肌质量指数（LVMI），并同期测定血清PTH、钙磷乘积，然后统计分析其相关关系。结果①试验组患者超声心动图结果显示，38．27％存在LVDd增大（49．33±6．78）mm，71．61％存在IVS增厚（12．57±2．58）mm，49．38％存在PWTH增厚（11．91±2．33）mm，30．51％存在EF下降（0．58±0．29）％，41．76％存在E／A下降（0．74±2．99），有93．90％出现左心室肥大（LVH）[LVMI（187．06±73．85）g／m^2]。②CKD3-5期患者LVMI改变与PTH、钙磷乘积呈正相关，且PTH与LVMI独立相关（P〈0．05）。结论CRF患者心血管疾病的发生率很高，心脏结构功能的变化与PTH、钙磷乘积密切相关，且PTH是LVMI的独立危险因素。
Objective To study the correlation between the left ventricular mass index （LVMI） and parathyroid hormone （PTH）, calcium-phosphorus product in chronic kidney disease （CKD） patients. Methods 81 patients with CKD and 30 healthy subjects served as control were enrolled in this study. LVDd,LVDs,IVS,PWTH,EF and E/A were measured by ultrasonic cardiogram. LVMI were calculated by the equation. Then the relationship between LVMI and PTH, calcium-phosphorus product were analyzed. Results The echocardiographic results of 81 patients indicated that there were 93.90% of LVH （LVMI 187.06±73.85g/m^2）. Among them, 38.27% had enlarged LVDd（49.33±6.78） mm, 71.61% had increased IVS（12.57±2.58）mm, 49.38% had increased PWTH（11. 91±2.33）mm, 30.51% had decreased EF（0.58±0. 29）%, 41.76% had decreased E/A（0. 74±2. 99）,and centrality reconstitution were 8. 54%. Statistical analysis showed a positive correlation between LVMI and PTH,calcium-phosphorus product. Conclusion There is a high incidence of cardiovascular disease in CRF patients. A close correlation exists between LVMI and disorders of phosphorus and calcium metabolism and between LVMI and PTH .
出处
《西部医学》
2008年第2期276-279,共4页
Medical Journal of West China
关键词
慢性肾脏疾病
超声心动图
左心室心肌质量指数
钙磷乘积
甲状旁腺激素
Chronic kidney disease
Ultrasonic cardiogram
Left ventricular mass index
Calcium-phosphorus product
Parathyroid hormone
