摘要
以妊娠双烯醇酮醋酸酯为起始原料,经过6步反应以15.0%的总收率,首次合成了孕甾-5,20-二烯-3β-醇-3-O-β-D-吡喃木糖苷.关键反应为选择性还原α,β-不饱和酮,夏皮罗反应,Koenig-Knorr反应.
The first synthesis of β-（pregna-5,20-diene-3β-yl）-D-xylopyranoside was achieved from 16-dehydropregnenolon-3β-yl acetate in six steps with a 15.0% overall yield. The key steps were selective reduction of α,β-unsaturated ketone, Shapiro reaction and Koenig-Knorr reactions.
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
2008年第5期587-590,共4页
Acta Chimica Sinica
基金
兰州大学青年学者创新研究基金(No.LZU200504)资助项目
