摘要
目的探讨环磷酰胺冲击疗法治疗重症紫癜性肾炎的疗效及不良反应。方法选择40例重症紫癜性肾炎患儿分为对照组和观察组,观察组给予CTX8～12mg(/kg·次),加入生理盐水100mL中静滴,累计剂量150mg/kg。对照组常规采用泼尼松1.5～2.0mg(/kg·d),双嘧达莫3～5mg/(kg·d)治疗。结果(1)40例HSPN中,单纯蛋白尿型2例(5.0%),单纯血尿加蛋白尿型12例(30.0%),肾炎综合征型8例(20.0%),急进性肾炎型3例(7.5%),肾病综合征型15例(33.0%);有胃肠道症状21例(52.5%),关节症状19例(47.5%)。(2)两组治疗后血浆总蛋白和清蛋白均高于治疗前(P<0.05～0.01);24h尿蛋白定量低于治疗前(P<0.05～0.01)。观察组治疗后血浆总蛋白、白蛋白较对照组明显上升(P<0.05),而24h尿蛋白定量下降明显(P<0.01);(3)观察组总有效率(80.0%)高于对照组(65.0%),不良反应低于对照组。结论采用CTX冲击方法治疗重症HSPN疗效好,且不良反应少。
Objective To observe the recent efficacy and side effect of intravenous cyclophospamide therapy on henochschoenle in purpura nephritis of children. Methods 40 cases of HSPN in children were divided into two groups： observation group and eontro] group. The observation group：8-12mg/ （kg·time） of CTX was added into 100mL of saline which was dropped intravenously a total dose of 150 mg/kg. The control group only applied prednisone and dipyridamole. Results （1）In 40 cases of HSPN, simple proteinuria type 2 eases（5.0%）, simple hematuria and proteinuria 12 eases（30.0%）, glomerulonephritis syndrome 8 eases（20.0%）, rapidly progressive glomernlo nephritis 3 eases（7.5%）, 15 eases of nephrotie syndrome（33.0%）. Gastrointestinal symptoms 21 eases （52.5%）, joint symptoms 19 cases（47.5%）. （2）In two groups after treatment plasma total protein and albumin were higher than before treatment（P〈0.05）; Less than 24 hours urinary protein governance before therapy（P〈0.05）; the observation group after treatmen, plasma total protein and albumin compared with the control group was significantly increased （P〈0.05）, while 24-hour urine protein decreased significantly（P〈0.01）; （3）The total efficiency（80.0%） in observation was higher than controls（65.0%）, adverse reactions lower than the control group. Conclusion The CTX concussion of a severe HSPN has good treatment efficacy, and fewer adverse reactions.
出处
《中国现代医生》
2008年第4期9-10,共2页
China Modern Doctor
关键词
环磷酰胺
紫癜性肾炎
疗效
Cyclophospamide
Purpura nephritis
Curative effect
