摘要
目的观察抗平滑肌抗体、抗核抗体与慢性乙肝肝纤维化程度的相关性。方法慢性乙肝患者223例,检测抗平滑肌抗体、抗核抗体,并与由年龄、血小板计数、γ-谷氨酰转肽酶及透明质酸四项指标构成的判别肝纤维化程度的指数模型(FibroIndex)比较,进行统计学分析。结果223例患者中有38例ASMA或(和)ANA阳性,29例患者为肝纤维化(≥S2),占76.3%;185例ASMA、ANA均为阴性的乙肝患者中107例患者为肝纤维化(≥S2),占57.8%;前者显著高于后者(P<0.05)。ASMA或(和)ANA在136例肝纤维化(≥S2)患者中的阳性检出率为21.3%(29/136),无纤维化患者中阳性检出率为7.1%(9/87);前者也显著高于后者(P<0.05)。结论抗核抗体或(和)抗平滑肌抗体阳性的慢性乙肝患者易发展成肝纤维化。
Objective To investigate the relationship of antismooth muscle antibody and antinuclear antibody with hepatic fibrosis of hepatitis B stage. Methods The ASMA and ANA of 223 patients with chronic hepatitis B were measured and compared with FibroIndex model conprised of age,blood platelets count,gama-glutamyltranspeptidase and hyaluronic acid. Results Among 223 chornic hepatitis B patients 38 cases were postive for ASMA and（or）ANA,29（76.3%） patients were diagnosed as hepatic fibrosis（≥S2）;107 of 185 chornic hepatitis B patients negative for ASMA and ANA were diagnosed as hepatic fibrosis（≥S2 ） ; the percentage of hepatic fibrosis of ASMA and（or） ANA positive group was higher than negative group（P〈0.05）. The precentage of ASMA and（or） ANA in hepatic fibrosis group was 21.3%（29/136） and 7.1% （9/87） in non-hepatic fibrosis group; the hepatic fibrosis group was higher than non-hepatic fibrosis group （P 〈 0.05 ）. Conclusion The detection of ASMA and（or） ANA can be a useful supplementary for evaluation hepatic fibrosis of hepatitis B stage.
出处
《中国现代医生》
2008年第3期8-9,共2页
China Modern Doctor
