摘要
目的:观察《普济方》中治疗积聚类疾病所用频次最高的中药大黄、当归、木香的不同配伍对Lewis肺癌荷瘤小鼠抑瘤作用的影响,探讨大黄当归木香的最佳配伍关系。方法:制备Lewis肺癌荷瘤小鼠动物模型,随机分为模型组、大黄组、大黄当归组、大黄木香组、大黄当归木香组;通过测定荷瘤小鼠的瘤重,计算抑瘤率,观察不同配伍组对肿瘤生长及对免疫功能的影响。结果:大黄当归组对Lewis肺癌的抑瘤率达到78.52%,脾指数(2.349±0.58)mg/g,与模型组比较,具有统计学意义(P<0.05)。结论:结合抑瘤率与脾指数,大黄当归组合在本次实验中作用最好。
Objective ：By observing the anti - tumor effect of Rhubarb, Radix Angelicae, Radix Aucklandia, which were most frequently used in treating abdominal mass in Prescripitons for Universal Relief, mixed with different ratio on those Holland lump mouse vaccinated with Lewis lung cancer, the best ratio of those three medicine was discussed. Methods ： Build up the models for Holland lump mouse vaccinated with Lewis lung cancer, and divided the mice into several groups for different medicine treatment using Rhubarb, Rhubarb plus Radix Aucklandia, Rhubarb plus Radix Angelicae, and Rhubarb plus Radix Angelicae and Radix Aucklandia, respectively. By measurement of the weight of tumors, calculate percentage of the anti - tumor effect for different medicine groups. Results ： In comparison with the model group, the group of Rhubarb plus Radix Aucklandia has the anti - tumor effect of 78.52% for Lewis lung cancer and spleen index is （2.349±0.58）mg/g which has statistics significance（ P 〈 0.05）. Both of these two medicine composition are with rather good anti - tumor effect （ P 〈 0. 05 ）. Conclusion ： Considering anti - tumor rate and spleen index, Rhubarb plus Radix Angelicae shows best effect of anti - tumor.
出处
《中华中医药学刊》
CAS
2008年第3期473-475,共3页
Chinese Archives of Traditional Chinese Medicine
基金
辽宁省科技厅资助项目(2003225006)
关键词
大黄
当归
木香
配伍比例
LEWIS肺癌
抑瘤作用
rhubarb
radix angelicae
radix aucklandia
mixing ratio
lewis lung cancer
anti - tumor effect
