摘要
目的探讨骨化性纤维瘤(ossifying fibroma,OF)与纤维结构不良(fibrousdys plasia,FD)的临床病理特征和免疫组化染色在鉴别诊断中的意义。方法对40例OF和26例FD进行临床及病理资料的回顾性研究,并应用免疫组化染色方法标记PCNA、Ki-67、Laminin、CK19。结果40例OF,包括青少年沙瘤样骨化性纤维瘤(juvenile psammomatoid ossifying fibroma,JPOF)8例与26例FD(单骨型14例,多骨型12例),两者平均年龄相近,OF男性常见,FD多骨型女性好发,平均年龄较小。OF好发于筛窦(75%),FD好发于蝶骨(58%)。26例OF(6例JPOF)及10例FD的免疫组织化学染色结果,经四格表x2检验PCNA染色结果有显著性差异,P<0.01。Ki-67、laminin及CK19无显著意义。结论OF与FD发病年龄、性别比例、好发部位、及临床症状不同,OF与FD免疫组化PCNA染色有助于两者的鉴别诊断。
OBJECTIVE To investigate the clinicopathological features of ossifying fibroma （OF） and fibrous dysplasia （FD）, and to evaluate the role of immunohistochemistry in differential diagnosis. METHODS Clinical presentation and morphological study of 40 cases with OF and 26 cases with FD were reviewed. Immunohistochemistry stains for PCNA, Ki-67, Laminin and CK 19 were performed in specimens of 10 cases with FD and 26 cases with OF. RESULTS The average age of OF was 22.2 years and the ratio of male and female was 2.33：1. The average age of FD was 17.2 years and the ratio of male and female is about1：1. The average age of the multibone type of FD was 11.2 years and the ratio of male and female is 1：2. Most of OF occurred in ethmoid sinus （75 %） and 70 % of the patients presented snuffle and hyposmia, while FD inclineed to arise from sphenoid （58 %） and 80.8 %of patients showed eyesight dropping and exophthalmos. The immunohistochemistry stains PCNA was positive in 19 cases （73.1%） of OF and negative in 10 cases of FD. Ki-67, laminin, CK19 were of little significance. CONCLUSION The gender, age distribution, clinical and pathological features of OF and FD are different from each other. Immunohistochemistry staining for PCNA is of great value in their differential diagnosis.
出处
《中国耳鼻咽喉头颈外科》
北大核心
2008年第2期64-66,共3页
Chinese Archives of Otolaryngology-Head and Neck Surgery
关键词
头颈部肿瘤
骨化性纤维瘤
纤维结构不良
骨
免疫组织化学
诊断
鉴别
Head and Neck Neoplasms
Ossifying Fibroma
Osteofibrous Dysplasia, Bons
Immunohistochemistry
Diagnosis, Differential
