摘要
目的观察对甲苯磺酰胺注射液（PTS）对大鼠移植性肝肿瘤局部注射的治疗作用并初步探讨其量效关系,为临床治疗肝癌提供参考。方法制作SD大鼠皮下移植性肝癌模型,取42只随机分为Ⅰ-Ⅵ组,每组7只。Ⅰ组为对照组,经皮向瘤体内注射生理盐水0.10ml;Ⅱ-Ⅵ组为实验组,分别经皮向瘤体内注射PTS 0.02、0.04、0.06、0.08、0.10ml;注射后24h处死,观察肿瘤组织病理变化。结果对照组肿瘤组织未见病理变化,瘤细胞生长活跃;PTS实验组于治疗后24h,肿瘤组织均出现范围不等的凝固性坏死,坏死范围随PTS注射剂量的增大而增大,注射剂量与肿瘤坏死区体积呈近似直线关系。其函数关系式为：肿瘤坏死区体积V（cm3）=-0.018＋2.595Y（Y为PTS注射剂量,单位ml）。结论抗肿瘤新药PTS瘤内局部注射肿瘤灭活作用量效关系密切,临床上可以根据肿瘤直径大小决定所需注射总量。
Objective To investigate the dose-effect relationship of para-toluenesulfonamide （PTS） for treatment of hepatocelluar carcinoma in rats. Methods Forty-two SD rats bearing subcutaneous transplanted hepatocellular carcinoma were randomly divided into 6 groups （n=7）, in which 0.02, 0.04, 0.06, 0.08, and 0.10 ml PTS and 0.10 ml normal saline were injected into the tumor, respectively. All of the rats were executed 24 h after the injection to observe the pathological changes in the tumor. Results In rats with saline injection, the tumor tissues exhibited no obvious changes and the tumor cells retained the active proliferation. ITS, in contrast, caused coagulation necrosis of the tumor tissue, and the necrotic area expanded with the increase of the injected doses. The necrotic volume of the tumor was in roughly linear correlation with the dose of PTS injected, with the linear regression equation of V （cm^3） =-0.018＋2.595Y （where V represents tumor necrosis volume, and Y the injected dose of ITS）. Conclusion The dose-effect relationship of ITS is roughly linear, and the ITS dose for injection can be estimated according to the diameter of the tumor.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2008年第2期249-251,共3页
Journal of Southern Medical University
关键词
对甲苯磺酰胺
肝肿瘤
量效关系
para-toluenesulfonamide
liver neoplasms
dose-effect relationship
