摘要
[目的]了解温州市海洛因依赖者戒断期血脂水平及其危险因素。[方法]对温州市戒毒所764例海洛因依赖者戒断期血压、身高、体重、体重指数(BMI)、血脂、丙氨酸氨基转移酶(ALT)等指标进行测定,并将其结果与同期在温州市体检中心进行健康体检的700名正常人群进行比较分析。[结果]海洛因依赖者总胆固醇(TC)、高密度脂蛋白(HDL-C)水平则显著低于正常人群(P<0.01),甘油三酯(TG)水平显著高于正常人群(P<0.01),低密度脂蛋白(LDL-C)差异无统计学意义(P<0.05)。高脂血症患病率高于正常人群(P<0.05),血脂异常患病率高于正常人群(P<0.05)。TC、TG和LDL-C水平与年龄正相关(P<0.01),TC、TG和LDL-C水平与BMI正相关(P<0.01),HDL-C与BMI负相关(P<0.01),TC和LDL-C水平与ALT负相关(P<0.01),海洛因依赖者血脂异常患病率与性别、BMI和ALT呈正相关(P<0.05),正常人群血脂异常患病率与年龄、性别和BMI呈正相关(P<0.05)。[结论]该市海洛因依赖者戒断期和正常人群的血脂模式、血脂异常患病率存在明显差异,可能与他们肝功能受损、低BMI和情绪障碍有关。
[ Objective ] To investigate the levels of blood fat and the risk factors in heroin addicts during the withdrawal period in Wenzhou city. [Methods] A total of 364 heroin addicts in the drug rehabilitation center of Wenzhou city were surveyed. Blood pressure, body height, body weight, blood fat and alanine aminotransferase （ALT） were measured, and surface areas and body mass index （BMI） were calculated. The results were compared with those in 700 healthy aduhs who were randomly selected at the same period in the medical examination center of Wenzhou. [ Results] Comparing with healthy adults. the values of total cholesterol （TC） and high-density lipoproteins （HDL-C） of heroin addicts were significantly, degraded （P 〈 0.01）, triglyceride （TG） values were significantly devated （P 〈 0.01 ）, low-density lipoproteins （LDL-C） values had no significance （P〉 0.05）. The prevalence rate of hyperlipoidemia in heroin addicts was significantly higher than that in healthy adults （P 〈 0.05）. The prevalence rate of abnormal blood fat in heroin addicts was significantly higher than that in health adults （P 〈 0.05）. The correlation analysis between BMI and TC, TG. HDL-C and LDL-C showed that the TC. TG and LDL-C had positive correlations with BMI （P 〈 0.01 ）, HDL-C had negative correlation with BMI （P 〈 0.01 ）, the correlation analysis between ALT and TC, TG, HDL-C and LDL-C showed that the TC. LDL-C had negative correlations with ALT （P 〈 0.01）. Therewas a positive correlation between gender, BMI, ALT and morbiditv of abnormal blood fat （P 〈 0.05 ） in heroin addicts. There was a positive correlation between age, gender, BMI and morbidity of abnormal blood fat （P〈 0.05） in healthy adults. [Conclusion] Comparing with healthy adults, the morbidity of abnormal blood fat in heroin addicts is significantly higher. The damage of liver function, low BMI and disorder of emotion may affect on the mode of blood fat in heroin addicts.
出处
《现代预防医学》
CAS
北大核心
2008年第5期813-816,818,共5页
Modern Preventive Medicine
基金
温州市科技计划项目资助(Y2005A052)
关键词
血脂异常
海洛因依赖
戎断期
患病率
Abnorrnal blood fat
Heroin addict
Withdrawal. Morbidity rate
