摘要
采用光照核黄素（LRF）产生氧自由基（OFR），观察后者在外周和脊髓水平对疼痛的影响．发现在外周，小鼠足跖部皮下注射（ipl）LRF0.067，0.67mmol.mouse-1有致痛作用，脊髓水平，小鼠鞘内注射LRF0．106～0，665nmol.mouse－1有致痛每作用;进一步研究发现OFR的脊髓痛敏与Ca2+有④切关系，用维拉帕米、尼莫地平、EGTA可拮抗OFR的痛敏作用．并证明阿斯匹林、吲哚美辛的镇痛作用与清除OFR有关．
By 1 ighting riboflavin to produce OFR, we studied the role of OFR in spinal and peripheral pain. Intraplantar injection (ipl) LRP at dose of 0.67 mmol/mice or 0.067mmol/mice in 0ne hind paw could induce peripheral pain. Intrathecal injection (ith) LRF 0.106~0.665nmol/mico could induce spinal hyperalgcsia. More research suggest that calcium might mediate the spinal hyperalgesia of OFR and scavenging PFR might involve itt the analgesia of ASP,IND.
出处
《中国现代应用药学》
CAS
CSCD
1997年第4期8-11,共4页
Chinese Journal of Modern Applied Pharmacy
关键词
氧自由基
阿斯匹林
吲哚美辛
镇痛
oxygen free radicals
Iighted ribotlavin
aspirin
indomethacin
