摘要
目的：探讨不同剂量肾上腺素对犬心脏骤停复苏时平均动脉压、血清肌钙蛋白Ｔ含量的影响。方法：健康杂种犬２４只，雌雄不拘，体重（１２．４±２．８）ｋｇ。按心脏复苏时肾上腺素给予的不同剂量分为Ａ、Ｂ、Ｃ、Ｄ４组，每组６只。复制犬急性心肌梗塞心室颤动模型，２４只犬随机分入上述实验组进行心肺复苏，测定复苏时主动脉压及平均动脉压，计算自主循环恢复率。用酶联免疫法测定肾上腺素给药后２．５分钟及７．５分钟时的血清肌钙蛋白Ｔ含量。结果：心脏复苏时大剂量肾上腺素组（Ｃ、Ｄ组）平均动脉压及自主循环恢复率显著高于标准剂量组（Ａ、Ｂ组），Ｐ＜０．０５；大剂量肾上腺素组７．５分钟的肌钙蛋白Ｔ含量显著高于２．５分钟的肌钙蛋白Ｔ含量（Ｐ均＜０．０５）；标准剂量肾上腺素组肌钙蛋白Ｔ含量在２．５分钟与７．５分钟时无显著性差异（Ｐ均＞０．０５）。结论：大剂量肾上腺素虽能提高犬心脏骤停复苏的成功率，但可加重心肌缺血及损伤程度。
Objective:To study effects of different doses of epinephrine on mean blood pressure and serum troponin T level during cardiopulmonary resuscitation in dogs.Methods:Twentyfour mongrel dogs,weighing (12 4±2 8)kg ,were randomly divided into four groups according to different doses of epinephrine (they were 0 02 mg/kg,0 05 mg/kg,0 10 mg/kg,0 20 mg/kg in group A,B,C,D respectively).A model of acute infarction ventricular fibrillation was replicated in dogs.Aortic pressure and mean blood pressure (MBP) were measured during cardiopulmonary resuscitation in those dogs,calculating the rate of return of spontaneous circulation (RSC).Also,serum troponin T (TNT) was assayed by enzyme linked immunosorbent assay at 2 5 and 7 5 minutes after different doses of epinephrine injected intravenously.Results:Mean blood pressure(MBP) and RSC rate in high dose epinephrine (HDE) groups(group C and D) were much higher than that in standard dose epinephrine (SDE) groups (group A and B)(all P <0 05).Serum TNT concentration at 7 5 minutes was higher significantly than that at 2 5 minutes after epinephrine injection in HDE groups(all P <0 05).In SDE groups,however,there were no marked differences in serum TNT concentration at various time points (all P >0 05).Conclusions:Although high dose epinephrine can improve MBP and RSC rate during cardiopulmonary resuscitation,it may exacerbate myocardial ischemia and damage in dogs.
出处
《中国危重病急救医学》
CSCD
1997年第8期462-463,共2页
Chinese Critical Care Medicine
基金
吉林省科委八五攻关课题资助
关键词
心脏骤停
心肺复苏
肌钙蛋白T
肾上腺素
cardiac arrest
cardiopulmonary resuscitation
epinephrine
serum troponin T
