摘要
目的:研究肿瘤患者血清IAP和T淋巴细胞等免疫指标与抑郁之间的关系.方法:对65例晚期肿瘤患者采用ZUNG量表进行抑郁调查,同时检测血清IAP、T淋巴细胞亚群和NK细胞数量,分析肿瘤患者抑郁与免疫功能之间的关系.结果:免疫功能与肿瘤部位、病情进展情况、性别之间无显著相关性,而抑郁与免疫功能检测指标之间呈显著相关:抑郁组肿瘤患者血清IAP和CD8高于非抑郁组(IAP:696.76±331.78 vs 499.03±233.74.P<0.01;CD8:36.65±14.20 vs 30.02±9.78,P<0.05),而NK和CD4低于非抑郁组(NK:17.03±11.36 vs 23.63±13.24.P<0.05;CD4:35.59±13.10 vs 41.41±8.14),CD3、CD4/CD8两组间比较无统计学差异:IAP与CD4和CD4/CD8呈负相关,与CD8呈正相关,与NK和CD3间无显著相关性.
AIM： To analyze the relationship between depression and immunity indexes such as imrnunosupressive acid protein （IAP） and T lymphocytes in cancer patients.
METHODS： Depression, IAP, subpopulation of T lymphocytes and natural killer cells were studied in 65 patients with advanced tumors. The relationship between depression and immune function in patients with or without depression was analyzed.
RESULTS： Compared to the control group, there was no difference in the location of cancer, evolvement of illness and sex in immunity function, while there was a difference in depression between other groups. The serum levels of IAP and CD8 were significantly higher in the depression group than in the control group （IAP： 696.76 ± 331.78 vs 499.03 ± 233.74, P 〈 0.01; CD8：36.65 ± 14.20 vs 30.02 ± 9.78, P 〈 0.05）. The serum levels of CD4 and NK were lower in the depression group than in the control group （NK： 17.03 ± 11.36 vs 23.63 ± 13.24, P 〈 0.05; CD4：35.59 ± 13.10 vs 41.41 ± 8.14）. There was no difference in the serum levels of CD3, CD4/CD8. IAP was negatively related with CD4 and CD4/CD8, and positively related with CD8. CD3 was not related with NK cells.
CONCLUSION： Depression is correlated with the immunity function in cancer patients.
出处
《世界华人消化杂志》
CAS
北大核心
2008年第3期335-337,共3页
World Chinese Journal of Digestology
关键词
肿瘤
抑郁
免疫抑制酸性蛋白
免疫
Cancer
Depression
Immunosuppres-sive acidic protein
Immunity
